Pulmonary arterial hypertension (PAH) is a relatively rare disease, but, today, its incidence
tends to increase. The severe course of the disease and poor patient survival rate make …

Immune checkpoint molecules function to inhibit and regulate immune response pathways
to prevent hyperactive immune activity from damaging healthy tissues. In cancer patients …

Background Increasing evidence suggests that microglial activation may participate in the
aetiology and pathogenesis of Parkinson's disease (PD). CD200-CD200R signalling has …

Background. Previous studies have shown that the interaction of CD200R, a myeloid
inhibitory receptor, with its ligand, CD200, is critical in the control of innate immune …

CD200 is a widely distributed membrane glycoprotein that regulates myeloid cell activity
through its interaction with an inhibitory receptor (CD200R). The interaction is of interest as a …

Paired receptors are families of membrane proteins characterized by similar extracellular
regions but different transmembrane and cytoplasmic regions, meaning that some members …

Coactivating and inhibitory receptors that share at least one ligand interact with a wide
variety of ligands, indicating their importance in a range of situations. Here, we discuss …

Abstract Objective. CD200/CD200R1 signalling has an immunoregulatory effect on the
activation threshold of the inflammatory immune response and maintains immune …

ABSTRACT CD200 is a cell surface glycoprotein that binds an inhibitory receptor (CD200R)
on myeloid cells. CD200 orthologues are present in many species of virus, and we show that …

The CD200 receptor (CD200R) is present mainly on myeloid cells and gives inhibitory
signals when engaged by its ligand CD200. The interaction is currently of therapeutic …