Significance of bystander T cell activation in microbial infection
During microbial infection, pre-existing memory CD8+ T cells that are not specific for the
infecting pathogens can be activated by cytokines without cognate antigens, termed …
infecting pathogens can be activated by cytokines without cognate antigens, termed …
Bystander CD4+ T cells: crossroads between innate and adaptive immunity
T cells are the central mediators of both humoral and cellular adaptive immune responses.
Highly specific receptor-mediated clonal selection and expansion of T cells assure antigen …
Highly specific receptor-mediated clonal selection and expansion of T cells assure antigen …
The pathogenicity and synergistic action of Th1 and Th17 cells in inflammatory bowel diseases
H Cao, J Diao, H Liu, S Liu, J Liu… - Inflammatory Bowel …, 2023 - academic.oup.com
Inflammatory bowel diseases (IBDs), including ulcerative colitis and Crohn's disease, are
characterized by chronic idiopathic inflammation of gastrointestinal tract. Although the …
characterized by chronic idiopathic inflammation of gastrointestinal tract. Although the …
The IL-18/IL-18R1 signalling axis: Diagnostic and therapeutic potential in hypertension and chronic kidney disease
Chronic kidney disease (CKD) is inherently an inflammatory condition, which ultimately
results in the development of end stage renal disease or cardiovascular events. Low-grade …
results in the development of end stage renal disease or cardiovascular events. Low-grade …
[HTML][HTML] Emerging role of bystander T cell activation in autoimmune diseases
CH Shim, S Cho, YM Shin, JM Choi - BMB reports, 2022 - ncbi.nlm.nih.gov
Autoimmune disease is known to be caused by unregulated self-antigen-specific T cells,
causing tissue damage. Although antigen specificity is an important mechanism of the …
causing tissue damage. Although antigen specificity is an important mechanism of the …
Risk factors for adverse outcomes of COVID-19 patients: Possible basis for diverse responses to the novel coronavirus SARS-CoV-2
M Ghaebi, S Tahmasebi, M Jozghorbani, A Sadeghi… - Life sciences, 2021 - Elsevier
Abstract Severe coronavirus disease 2019 (COVID-19) caused by the Severe Acute
Respiratory Syndrome coronavirus 2 (SARS-CoV-2) is characterized by an unpredictable …
Respiratory Syndrome coronavirus 2 (SARS-CoV-2) is characterized by an unpredictable …
IL-1R signaling promotes STAT3 and NF-κB factor recruitment to distal cis-regulatory elements that regulate Il17a/f transcription
SK Whitley, A Balasubramani, CL Zindl, R Sen… - Journal of Biological …, 2018 - ASBMB
Interleukin (IL)-1β plays a critical role in IL-6β–and transforming growth factor β (TGFβ)–
initiated Th17 differentiation and induction of Th17-mediated autoimmunity. However, the …
initiated Th17 differentiation and induction of Th17-mediated autoimmunity. However, the …
[HTML][HTML] Targeting Interleukin-17 as a novel treatment option for fibrotic diseases
Fibrosis is the end result of persistent inflammatory responses induced by a variety of stimuli,
including chronic infections, autoimmune reactions, and tissue injury. Fibrotic diseases affect …
including chronic infections, autoimmune reactions, and tissue injury. Fibrotic diseases affect …
Transition from metal-DTH resistance to susceptibility is facilitated by NLRP3 inflammasome signaling induced Th17 reactivity: Implications for orthopedic implants
Metal hypersensitivity has been recognized as an adverse biologic reaction that can
compromise total joint arthroplasty (TJA) performance. However, the etiology of metal …
compromise total joint arthroplasty (TJA) performance. However, the etiology of metal …
Mechanisms governing bystander activation of T cells
M Yosri, M Dokhan, E Aboagye… - Frontiers in …, 2024 - frontiersin.org
The immune system is endowed with the capacity to distinguish between self and non-self,
so-called immune tolerance or “consciousness of the immune system.” This type of …
so-called immune tolerance or “consciousness of the immune system.” This type of …