Analysis of a SARS-CoV-2-infected individual reveals development of potent neutralizing antibodies with limited somatic mutation

E Seydoux, LJ Homad, AJ MacCamy, KR Parks… - Immunity, 2020 - cell.com
Antibody responses develop following SARS-CoV-2 infection, but little is known about their
epitope specificities, clonality, binding affinities, epitopes, and neutralizing activity. We …

Natural selection in the evolution of SARS-CoV-2 in bats created a generalist virus and highly capable human pathogen

OA MacLean, S Lytras, S Weaver, JB Singer… - PLoS …, 2021 - journals.plos.org
Virus host shifts are generally associated with novel adaptations to exploit the cells of the
new host species optimally. Surprisingly, Severe Acute Respiratory Syndrome Coronavirus …

Structural basis of odorant recognition by a human odorant receptor

CB Billesbølle, CA de March, WJC van der Velden… - Nature, 2023 - nature.com
Our sense of smell enables us to navigate a vast space of chemically diverse odour
molecules. This task is accomplished by the combinatorial activation of approximately 400 …

Metacoder: An R package for visualization and manipulation of community taxonomic diversity data

ZSL Foster, TJ Sharpton… - PLoS computational …, 2017 - journals.plos.org
Community-level data, the type generated by an increasing number of metabarcoding
studies, is often graphed as stacked bar charts or pie graphs that use color to represent taxa …

Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion

PP Centeno, A Herberger, HC Mun, C Tu… - Nature …, 2019 - nature.com
Extracellular phosphate regulates its own renal excretion by eliciting concentration-
dependent secretion of parathyroid hormone (PTH). However, the phosphate-sensing …

Building megaphylogenies for macroecology: taking up the challenge

C Roquet, W Thuiller, S Lavergne - Ecography, 2013 - Wiley Online Library
The last decades have seen an upsurge in ecological studies incorporating phylogenetic
information with increasing species samples, motivated by the common conjecture that …

Proteome-wide signatures of function in highly diverged intrinsically disordered regions

T Zarin, B Strome, AN Nguyen Ba, S Alberti… - Elife, 2019 - elifesciences.org
Intrinsically disordered regions make up a large part of the proteome, but the sequence-to-
function relationship in these regions is poorly understood, in part because the primary …

Tuberculosis treatment failure associated with evolution of antibiotic resilience

Q Liu, J Zhu, CL Dulberger, S Stanley, S Wilson… - Science, 2022 - science.org
The widespread use of antibiotics has placed bacterial pathogens under intense pressure to
evolve new survival mechanisms. Genomic analysis of 51,229 Mycobacterium tuberculosis …

Predicting reservoir hosts and arthropod vectors from evolutionary signatures in RNA virus genomes

SA Babayan, RJ Orton, DG Streicker - Science, 2018 - science.org
Identifying the animal origins of RNA viruses requires years of field and laboratory studies
that stall responses to emerging infectious diseases. Using large genomic and ecological …

The coevolution of fungus-ant agriculture

TR Schultz, J Sosa-Calvo, MP Kweskin, MW Lloyd… - Science, 2024 - science.org
Fungus-farming ants cultivate multiple lineages of fungi for food, but, because fungal cultivar
relationships are largely unresolved, the history of fungus-ant coevolution remains poorly …