Recent structural information for complexes of cytokine receptor ectodomains bound to their
ligands has significantly expanded our understanding of the macromolecular topology and …

Interleukin-31, produced mainly by activated CD4+ T cells, is a newly discovered member of
the gp130/IL-6 cytokine family. Unlike all the other family members, IL-31 does not engage …

Interleukin-6 (IL-6) is an immunoregulatory cytokine that activates a cell-surface signaling
assembly composed of IL-6, the IL-6 α-receptor (IL-6Rα), and the shared signaling receptor …

Interleukin-6 (IL-6) is a pleiotropic cytokine that activates a classic signalling pathway upon
binding to its membrane-bound receptor (IL-6R). Alternatively, IL-6 may 'trans-signal'in a …

Asthma and atopy show epidemiological association and are biologically linked by T-helper
type 2 (Th2) cytokine-driven inflammatory mechanisms. IL-4 operates through the IL-4 …

Cytokines are small signaling proteins that have central roles in inflammation and cell
survival. In the half-century since the discovery of the first cytokines, the interferons, over fifty …

Interleukin-4 (IL-4) and IL-13 are the only cytokines known to bind to the receptor chain IL-
4Rα. Receptor sharing by these two cytokines is the molecular basis for their overlapping …

Leukemia-inhibitory factor (LIF) is a pleiotropic cytokine expressed by multiple tissue types.
The LIF receptor shares a common gp130 receptor subunit with the IL-6 cytokine …

The activation of gp130, a shared signal-transducing receptor for a family of cytokines, is
initiated by recognition of ligand followed by oligomerization into a higher order signaling …

Cytokines of the gp130 family exert their diverse biological effects by formation of stable high
affinity transmembrane receptor complexes that are characterized by the presence of the …