The first direct oral anticoagulant (DOAC) to be approved for clinical use was dabigatran, a
direct thrombin inhibitor, in 2010. Since that time, four additional DOACs, all direct anti‐Xa …

In 2018, the International Council for Standardization in Haematology (ICSH) published a
consensus document providing guidance for laboratories on measuring direct oral …

Background Severe traumatic injury continues to present challenges to healthcare systems
around the world, and post-traumatic bleeding remains a leading cause of potentially …

This guidance document was prepared on behalf of the International Council for
Standardization in Haematology (ICSH) for providing haemostasis-related guidance …

ORCA – Online Research @ Cardiff Page 1 ORCA – Online Research @ Cardiff This is an
Open Access document downloaded from ORCA, Cardiff University's institutional repository:https://orca.cardiff.ac.uk/id/eprint/115006 …

In urgent clinical situations, such as trauma, urgent surgery or before thrombolysis, rapid
quantification of direct oral anticoagulant plasma drug levels is warranted. Using the …

This review provides a comprehensive and up-to-date overview of point-of-care (POC)
devices most commonly used for coagulation analyses in the acute settings. Fast and …

New guideline recommendations prefer direct oral anticoagulants (DOACs) over warfarin in
DOAC-eligible patients with atrial fibrillation and patients with venous thromboembolism. As …

BACKGROUND The trauma patient on direct oral anticoagulant (DOAC) therapy preinjury
presents a challenge in trauma and acute care surgery. Our understanding of these patients …

Background The ability to assess the hemostatic effect of the direct oral anticoagulant
(DOACs) may be valuable in clinical situations such as bleeding or thrombosis, before …