Antifungal agents: spectrum of activity, pharmacology, and clinical indications
Continued advancement of medical science offers life-saving treatment options for a variety
of hematologic, oncologic, and rheumatologic conditions. Immunosuppression, a common …
of hematologic, oncologic, and rheumatologic conditions. Immunosuppression, a common …
Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance
MA Ghannoum, LB Rice - Clinical microbiology reviews, 1999 - Am Soc Microbiol
The increased use of antibacterial and antifungal agents in recent years has resulted in the
development of resistance to these drugs. The significant clinical implication of resistance …
development of resistance to these drugs. The significant clinical implication of resistance …
Current and emerging azole antifungal agents
DJ Sheehan, CA Hitchcock… - Clinical microbiology …, 1999 - Am Soc Microbiol
Major developments in research into the azole class of antifungal agents during the 1990s
have provided expanded options for the treatment of many opportunistic and endemic fungal …
have provided expanded options for the treatment of many opportunistic and endemic fungal …
Voriconazole: a new triazole antifungal agent
LD Saravolatz, LB Johnson… - Clinical infectious …, 2003 - academic.oup.com
The 1990s witnessed an expansion of the antifungal armamentarium to include 2 new azole
agents, fluconazole and itraconazole. These agents changed our approach to treating many …
agents, fluconazole and itraconazole. These agents changed our approach to treating many …
Mechanism of Fluconazole Resistance in Candida albicans Biofilms: Phase-Specific Role of Efflux Pumps and Membrane Sterols
PK Mukherjee, J Chandra, DM Kuhn… - Infection and …, 2003 - Am Soc Microbiol
Candida albicans biofilms are formed through three distinct developmental phases and are
associated with high fluconazole (FLU) resistance. In the present study, we used a set of …
associated with high fluconazole (FLU) resistance. In the present study, we used a set of …
Natural product based leads to fight against leishmaniasis
The growing incidence of parasitic resistance against generic pentavalent antimonials,
specifically for visceral disease in Indian subcontinent, is a serious issue in Leishmania …
specifically for visceral disease in Indian subcontinent, is a serious issue in Leishmania …
Pharmacokinetics and safety of voriconazole following intravenous-to oral-dose escalation regimens
L Purkins, N Wood, P Ghahramani… - Antimicrobial agents …, 2002 - Am Soc Microbiol
In this study, the safety, tolerability, and pharmacokinetics of intravenous (iv)-to oral-dose
regimens of voriconazole were evaluated with a group of 42 healthy men, 41 of whom …
regimens of voriconazole were evaluated with a group of 42 healthy men, 41 of whom …
Antifungal drug resistance to azoles and polyenes
MM Canuto, FG Rodero - The Lancet infectious diseases, 2002 - thelancet.com
There is an increased awareness of the morbidity and mortality associated with fungal
infections caused by resistant fungi in various groups of patients. Epidemiological studies …
infections caused by resistant fungi in various groups of patients. Epidemiological studies …
Voriconazole
LA Jeu, FJ Piacenti, AG Lyakhovetskiy, HB Fung - Clinical therapeutics, 2003 - Elsevier
Background: Reports of resistance and intolerance to currently available antifungal agents
are increasing. Voriconazole is a broad-spectrum azole antifungal agent structurally derived …
are increasing. Voriconazole is a broad-spectrum azole antifungal agent structurally derived …
Antileishmanial drug discovery: Comprehensive review of the last 10 years
Leishmaniasis, a group of diseases caused by hemoflagellate obligate intracellular protozoa
(trypanosomatids) from the genus Leishmania, has not received the attention it deserves …
(trypanosomatids) from the genus Leishmania, has not received the attention it deserves …