The field of cAMP signaling is witnessing exciting developments with the recognition that
cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal …

This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

The ryanodine receptor (RyR)/calcium release channel on the sarcoplasmic reticulum (SR)
is the major source of calcium (Ca 2+) required for cardiac muscle excitation-contraction …

Multiprotein signalling networks create focal points of enzyme activity that disseminate the
intracellular action of many hormones and neurotransmitters. Accordingly, the spatio …

Taskén, Kjetil, and Einar Martin Aandahl. Localized Effects of cAMP Mediated by Distinct
Routes of Protein Kinase A. Physiol Rev 84: 137–167, 2004; 10.1152/physrev. 00021.2003 …

General cognitive function is substantially heritable across the human life course from
adolescence to old age. We investigated the genetic contribution to variation in this …

Cellular signal transmission requires the dynamic formation of spatiotemporally controlled
molecular interactions. At the cell surface information is received by receptor complexes and …

Abstract Cyclic adenosine 3′, 5′-monophosphate (cAMP) is a ubiquitous mediator of
intracellular signalling events. It acts principally through stimulation of cAMP-dependent …

In search of vascular smooth muscle cell differentiation markers, we identified two genes
encoding members of a new family of type II integral membrane proteins. Both are …

Spatiotemporal regulation of protein kinase A (PKA) activity involves the manipulation of
compartmentalized cAMP pools. Now we demonstrate that the muscle‐selective A‐kinase …