Transition metal ions and neurotransmitters: coordination chemistry and implications for neurodegeneration

J Yoo, J Han, MH Lim - RSC Chemical Biology, 2023 - pubs.rsc.org
Neurodegeneration is characterized by a disturbance in neurotransmitter-mediated
signaling pathways. Recent studies have highlighted the significant role of transition metal …

Methods for analyzing the coordination and aggregation of metal–amyloid-β

S Park, C Na, J Han, MH Lim - Metallomics, 2023 - academic.oup.com
The misfolding and aggregation of amyloid-β (Aβ) peptides are histopathological features
found in the brains of Alzheimer's disease (AD). To discover effective therapeutics for AD …

Copper (II) Affects the Biochemical Behavior of Proinsulin C-peptide by Forming Ternary Complexes with Serum Albumin

JA San Juan, K Chakarawet, Z He… - Journal of the …, 2023 - ACS Publications
Peptide hormones are essential signaling molecules with therapeutic importance. Identifying
regulatory factors that drive their activity gives important insight into their mode of action and …

Bright Green-Emissive Carbon Nanodots for Sensing and Intracellular Imaging of Cu2+ and Glutathione

Z Guo, Y Zhu, Y Xu, P Miao - ACS Applied Bio Materials, 2023 - ACS Publications
Green-emissive carbon nanodots (CDs) with high quantum yield are prepared. The
abundant functional groups on the surfaces of CDs can selectively interact with Cu2+. The …

Transition Metal Ion FRET-Based Probe to Study Cu (II)-Mediated Amyloid-β Ligand Binding

R Wu, D Svingou, JB Metternich… - Journal of the …, 2024 - ACS Publications
Recent therapeutic strategies suggest that small peptides can act as aggregation inhibitors
of monomeric amyloid-β (Αβ) by inducing structural rearrangements upon complexation …

The structure of cyclic neuropeptide somatostatin and octapeptide octreotide in the presence of copper ions: Insights from transition metal ion FRET and native ion …

R Wu, LR Benzenberg, D Svingou… - Journal of the American …, 2023 - ACS Publications
The conformation and function of somatostatin (SST), a cyclic neuropeptide, was recently
found to be altered in the presence of Cu (II) ions, which leads to self-aggregation and loss …

Revealing the Nanoarchitectonics of Amyloid β‐Aggregation on Two‐Dimensional Biomimetic Membranes by Surface‐Enhanced Infrared Absorption Spectroscopy

M Zhu, L Zeng, Z Li, C Wang, L Wu, X Jiang - ChemistryOpen, 2023 - Wiley Online Library
The in vivo folding of amyloid β (Aβ) is influenced by many factors among which
biomembrane interfaces play an important role. Here, using surface‐enhanced infrared …

Native Mass Spectrometry-Centric Approaches Revealed That Neuropeptides Frequently Interact with Amyloid-β

D Wang, G Wang, X Wang, Z Ren… - ACS Chemical …, 2024 - ACS Publications
Amyloid-β (Aβ) aggregates are recognized as initiators of Alzheimer's disease, and their
interaction with the nervous system contributes to the progression of neurodegeneration …

Concentration Effect, Structural Properties, and Driving Force on Aβ28 Dimerization with and without Zn2+ Cooperation: Learning from Replica Exchange Sampling …

Y Sun, Z Yao, G Wang, L Wang, M Bai… - ChemPhysChem, 2023 - Wiley Online Library
Zn2+ is a very important factor in promoting the formation of amyloid beta (Aβ) aggregates
and amyloid plaques. The Zn2+‐bound Aβ species generate amorphous or low molecular …

Catalytic function of zinc finger proteins against amyloid-amyloidogenesis

S Park, Y Hwang, Y Lin, J Kwak, E Nam, J Han… - 2024 - chemrxiv.org
Zinc finger (ZF) proteins are integral to neurological processes by mediating biomolecular
interactions and regulating gene expression. Despite their implication in neurodegenerative …