During development, both cells and tissues must acquire the correct shape to allow their
proper function. This is especially relevant in the nervous system, where the shape of …

The extracellular matrix (ECM) regulates cell behavior by influencing cell proliferation,
survival, shape, migration and differentiation. Far from being a static structure, the ECM is …

There is currently an unmet need for the supply of autologous, patient-specific stem cells for
regenerative therapies in the clinic. Mesenchymal stem cell differentiation can be driven by …

Gliomas are a diverse group of primary central nervous system tumors that affect both
children and adults. Recent studies have revealed a dynamic cross talk that occurs between …

Although vascular endothelial growth factor (VEGF) receptor 2 (VEGFR2) is traditionally
regarded as an endothelial cell protein, evidence suggests that VEGFRs may be expressed …

Recent evidence shows that transplantation of neural stem/precursor cells may protect the
central nervous system from inflammatory damage through a'bystander'mechanism that is …

Graft survival and integration are major factors that limit the efficacy of cell therapies for the
treatment of disease and injury in the central nervous system. Efforts to improve cell survival …

Stem cells are captivating because they have the potential to make multiple cell types yet
maintain their undifferentiated state. Recent studies of Drosophila and mammalian neural …

The mammalian cerebral cortex is the pinnacle of brain evolution, reaching its maximum
complexity in terms of neuron number, diversity and functional circuitry. The emergence of …

Integrins are transmembrane proteins that mediate cellular adhesion and migration to
neighboring cells or the extracellular matrix, which is essential for cells to undertake diverse …