Reactive crystallization: a review

MA McDonald, H Salami, PR Harris… - Reaction Chemistry & …, 2021 - pubs.rsc.org
Reactive crystallization is not new, but there has been recent growth in its use as a means of
improving performance and sustainability of industrial processes. This review examines …

Semi-continuous and continuous processes for enantiomeric separation

M Ciriani, R Oliveira, CAM Afonso - Green Chemistry, 2022 - pubs.rsc.org
Chiral resolution is an operation of great interest and increasing importance for the scientific
community and industry. There are two approaches to provide enantiomerically pure …

Progress to date in the design and operation of continuous crystallization processes for pharmaceutical applications

B Wood, KP Girard, CS Polster… - … Process Research & …, 2019 - ACS Publications
Continuous crystallization has gained interest in the pharmaceutical sector as part of the
drive toward the transition from exclusive batch manufacturing to integrated continuous …

Mechanisms and control of impurities in continuous crystallization: a review

C Darmali, S Mansouri, N Yazdanpanah… - Industrial & …, 2018 - ACS Publications
Crystallization has been applied to a broad range of industries such as bulk and fine
chemicals and the pharmaceutical and food industries. It is important to strategically control …

Enhanced sustainability with crystallization in continuous flow

P Neugebauer, S Soritz, JG Khinast… - Current Opinion in …, 2024 - Elsevier
At a time of rising raw material and energy prices, as well as growing awareness of the
green transition approach, sustainability is becoming an increasingly important issue in the …

[HTML][HTML] A synthetic machine learning framework for complex crystallization processes: The case study of the second-order asymmetric transformation of enantiomers

EA Kovács, B Szilágyi - Chemical Engineering Journal, 2023 - Elsevier
Improving the flexibility and capabilities of pharmaceutical technologies and lowering the
process development time while satisfying regulatory constraints translate to highly desired …

Form selection of concomitant polymorphs: A case study informed by crystallization kinetics modeling

W Tang, Y Quan, J Gong, J Wang, Q Yin, T Li - AIChE Journal, 2021 - Wiley Online Library
Molecular mechanisms and process kinetics of crystallizing concomitant polymorphs remain
poorly understood. Solvent‐mediated phase transformation and concomitant crystallization …

Solid-state deracemization via temperature cycles in continuous operation: Model-based process design

B Bodák, M Mazzotti - Crystal Growth & Design, 2022 - ACS Publications
Solid-state deracemization via temperature cycles converts a racemic crystal mixture into an
enantiopure product by periodic cycling of the temperature in the presence of a racemization …

Continuous chiral inversion by coupling enzymatic racemization with enantioselective fluidized bed crystallization

J Gänsch, K Oliynyk, S Potharaju… - Industrial & …, 2024 - ACS Publications
In this study, the continuous chiral inversion of an undesired but cheap and readily available
enantiomer into a desired valuable target enantiomer via coupling enzymatic racemization …

[HTML][HTML] On the model-based design and comparison of crystallization-based deracemization techniques

B Bodák, F Breveglieri, M Mazzotti - Chemical Engineering Science, 2022 - Elsevier
Deracemization techniques produce target enantiomer (eutomer) by converting the
undesired enantiomer (distomer) through a racemization reaction. We identify four …