The gene SCN5A encodes the main cardiac sodium channel Na V 1.5. This channel
predominates the cardiac sodium current, I Na, which underlies the fast upstroke of the …

Background Disease-modifying single nucleotide polymorphisms (SNPs) can help explain
incomplete penetrance and variable expressivity in congenital long QT syndrome (LQTS) by …

SCN5A encodes the voltage-gated Na+ channel NaV1. 5 that is responsible for
depolarization of the cardiac action potential and rapid intercellular conduction. Mutations …

In recent years genome-wide association studies (GWAS) have uncovered numerous
chromosomal loci associated with various electrocardiographic traits and cardiac arrhythmia …

Genome-wide association studies have identified a wealth of genetic variants involved in
complex traits and multifactorial diseases. There is now considerable interest in testing …

Advances in genome-wide association studies (GWAS) and large-scale sequencing studies
have resulted in an impressive and growing list of disease-and trait-associated genetic …

The goal of this study was to investigate the contribution of NOS1AP-promoter DNA
methylation to the risk of intracranial aneurysm (IA) and brain arteriovenous malformation …

Motivation Fine mapping is a widely used approach for identifying the causal variant (s) at
disease-associated loci. Standard methods (eg multiple regression) require individual level …

Background There is a genetic contribution to the risk of ventricular arrhythmias in survivors
of acute coronary syndromes (ACS). We wished to explore the role of 33 candidate single …

In this work we study variable-significance in classification using the Random Forest
proximity matrix and local Importance matrix. We use the proximity matrix to group the …