Spasticity and its contribution to hypertonia in cerebral palsy

L Bar-On, G Molenaers, E Aertbeliën… - BioMed research …, 2015 - Wiley Online Library
Spasticity is considered an important neural contributor to muscle hypertonia in children with
cerebral palsy (CP). It is most often treated with antispasticity medication, such as Botulinum …

Over 25 years of pediatric botulinum toxin treatments: what have we learned from injection techniques, doses, dilutions, and recovery of repeated injections?

H Sätilä - Toxins, 2020 - mdpi.com
Botulinum toxin type A (BTXA) has been used for over 25 years in the management of
pediatric lower and upper limb hypertonia, with the first reports in 1993. The most common …

Muscle growth is reduced in 15‐month‐old children with cerebral palsy

A Herskind, A Ritterband‐Rosenbaum… - … Medicine & Child …, 2016 - Wiley Online Library
Aim Lack of muscle growth relative to bone growth may be responsible for development of
contractures in children with cerebral palsy (CP). Here, we used ultrasonography to …

Impaired muscle growth precedes development of increased stiffness of the triceps surae musculotendinous unit in children with cerebral palsy

M Willerslev‐Olsen, M Choe Lund… - … Medicine & Child …, 2018 - Wiley Online Library
Aim If increased muscle stiffness and contractures in children with cerebral palsy (CP) are
related to impaired muscle growth, reduced muscle growth should precede or coincide with …

Neuro-musculoskeletal simulation of instrumented contracture and spasticity assessment in children with cerebral palsy

MM van der Krogt, L Bar-On, T Kindt… - … of neuroengineering and …, 2016 - Springer
Background Increased resistance in muscles and joints is an important phenomenon in
patients with cerebral palsy (CP), and is caused by a combination of neural (eg spasticity) …

Enhancing KCC2 activity decreases hyperreflexia and spasticity after chronic spinal cord injury

JN Bilchak, K Yeakle, G Caron, D Malloy… - Experimental neurology, 2021 - Elsevier
After spinal cord injury (SCI), the majority of individuals develop spasticity, a debilitating
condition involving involuntary movements, co-contraction of antagonistic muscles, and …

Science-based neurorehabilitation: recommendations for neurorehabilitation from basic science

JB Nielsen, M Willerslev-Olsen… - Journal of motor …, 2015 - Taylor & Francis
Neuroscience has fundamentally changed the understanding of learning and memory within
recent years. Here, the authors discuss a number of specific areas where they believe new …

The impact of strength training on skeletal muscle morphology and architecture in children and adolescents with spastic cerebral palsy: a systematic review

JG Gillett, RN Boyd, CP Carty, LA Barber - Research in developmental …, 2016 - Elsevier
Aim The aim of this study was to systematically review the current literature to determine the
impact of strength training on skeletal muscle morphology and architecture in individuals …

Stretching interventions in children with cerebral palsy: why are they ineffective in improving muscle function and how can we better their outcome?

BM Kalkman, L Bar-On, TD O'Brien… - Frontiers in …, 2020 - frontiersin.org
Hyper-resistance at the joint is one of the most common symptoms in children with cerebral
palsy (CP). Alterations to the structure and mechanical properties of the musculoskeletal …

Maturation of the locomotor circuitry in children with cerebral palsy

G Cappellini, F Sylos-Labini, AH Dewolf… - … in Bioengineering and …, 2020 - frontiersin.org
The first years of life represent an important phase of maturation of the central nervous
system, processing of sensory information, posture control and acquisition of the locomotor …