The relevance of dosimetry in precision medicine

M Lassmann, U Eberlein - Journal of Nuclear Medicine, 2018 - Soc Nuclear Med
The aim of this review is to provide an overview of the most recent technologic
developments in state-of-the-art equipment and tools for dosimetry in radionuclide therapies …

SPECT image segmentation for estimation of tumour volume and activity concentration in 177Lu-DOTATATE radionuclide therapy

J Gustafsson, A Sundlöv, K Sjögreen Gleisner - EJNMMI research, 2017 - Springer
Background Dosimetry in radionuclide therapy has the potential to allow for a treatment
tailored to the individual patient. One therapeutic radiopharmaceutical where patient-specific …

Experimental validation of absolute SPECT/CT quantification for response monitoring in breast cancer

A Collarino, LM Pereira Arias‐Bouda… - Medical …, 2018 - Wiley Online Library
Purpose Recent developments in iterative image reconstruction enable absolute
quantification of SPECT/CT studies by incorporating compensation for collimator–detector …

Inclusion of quasi-vertex views in a brain-dedicated multi-pinhole SPECT system for improved imaging performance

B Auer, N Zeraatkar, JC Goding, A Könik… - Physics in Medicine …, 2021 - iopscience.iop.org
With brain-dedicated multi-detector systems employing pinhole apertures the usage of
detectors facing the top of the patient's head (ie quasi-vertex (QV) views) can provide the …

The Challenge of Single-Photon Emission Computed Tomography Image Segmentation in the Internal Dosimetry of 177Lu Molecular Therapies

J Gawel, Z Rogulski - Journal of Imaging, 2024 - mdpi.com
The aim of this article is to review the single photon emission computed tomography
(SPECT) segmentation methods used in patient-specific dosimetry of 177Lu molecular …

The accuracy and reproducibility of SPECT target volumes and activities estimated using an iterative adaptive thresholding technique

J Grimes, A Celler, S Shcherbinin… - Nuclear medicine …, 2012 - journals.lww.com
Objective Our aim was to design a practical and reproducible image segmentation method
for calculations of total absorbed doses in organs and tumours for internally delivered …

Impact of SPECT corrections on 3D‐dosimetry for liver transarterial radioembolization using the patient relative calibration methodology

M Pacilio, M Ferrari, C Chiesa, L Lorenzon… - Medical …, 2016 - Wiley Online Library
Purpose: Many centers aim to plan liver transarterial radioembolization (TARE) with
dosimetry, even without CT‐based attenuation correction (AC), or with unoptimized scatter …

New strategy for automatic tumor segmentation by adaptive thresholding on PET/CT images

M Moussallem, PJ Valette… - Journal of applied …, 2012 - Wiley Online Library
Tumor delineation is a critical aspect in radiotherapy treatment planning and is usually
performed with the anatomical images of a computed tomography (CT) scan. For non‐small …

Simplifying volumes‐of‐interest (VOIs) definition in quantitative SPECT: beyond manual definition of 3D whole‐organ VOIs

EM Vicente, MA Lodge, SP Rowe, RL Wahl… - Medical …, 2017 - Wiley Online Library
Purpose We investigated the feasibility of using simpler methods than manual whole‐organ
volume‐of‐interest (VOI) definition to estimate the organ activity concentration in single …

Including anatomical and functional information in MC simulation of PET and SPECT brain studies. Brain-VISET: A voxel-based iterative method

B Marti-Fuster, O Esteban, K Thielemans… - … on medical imaging, 2014 - ieeexplore.ieee.org
Monte Carlo (MC) simulation provides a flexible and robust framework to efficiently evaluate
and optimize image processing methods in emission tomography. In this work we present …