Division in synthetic cells

MY Chang, H Ariyama, WTS Huck… - Chemical Society reviews, 2023 - pubs.rsc.org
The bottom-up construction of a living cell using non-living materials represents a grand
challenge in science and technology. Reproduction of cells into similar offspring is key to …

Active coacervate droplets are protocells that grow and resist Ostwald ripening

KK Nakashima, MHI van Haren, AAM André… - Nature …, 2021 - nature.com
Active coacervate droplets are liquid condensates coupled to a chemical reaction that turns
over their components, keeping the droplets out of equilibrium. This turnover can be used to …

[HTML][HTML] Emerging delivery systems based on aqueous two-phase systems: A review

Y Zhang, Y Luo, J Zhao, W Zheng, J Zhan… - … Pharmaceutica Sinica B, 2024 - Elsevier
The aqueous two-phase system (ATPS) is an all-aqueous system fabricated from two
immiscible aqueous phases. It is spontaneously assembled through physical liquid-liquid …

Temperature-responsive peptide–nucleotide coacervates

T Lu, KK Nakashima, E Spruijt - The Journal of Physical Chemistry …, 2021 - ACS Publications
Coacervates are a type of liquid–liquid phase separated (LLPS) droplets that can serve as
models of membraneless organelles (MLOs) in living cells. Peptide–nucleotide coacervates …

Mass transfer of chemical absorption of CO2 in a serpentine minichannel

Z Pang, S Jiang, C Zhu, Y Ma, T Fu - Chemical Engineering Journal, 2021 - Elsevier
Based on the online method, the absorption kinetics and mass transfer of CO 2 in potassium
carbonate solution in a serpentine minichannel are studied. Three flow patterns are …

Lipid coated protein condensates as stable protocells with selective uptake abilities for biomolecules

J Son, Y Jung - Chemical Science, 2022 - pubs.rsc.org
To create cell-like synthetic systems, spatial confinement that is stable against
environmental changes and selective uptake of diverse biomolecules into these …

Coacervate microdroplets as synthetic protocells for cell mimicking and signaling communications

Z Wang, M Zhang, Y Zhou, Y Zhang, K Wang… - Small …, 2023 - Wiley Online Library
Synthetic protocells are minimal systems that mimic certain properties of natural cells and
are used to research the emergence of life from a nonliving chemical network. Currently …

[HTML][HTML] Recent developments in microfluidic synthesis of artificial cell-like polymersomes and liposomes for functional bioreactors

H Seo, H Lee - Biomicrofluidics, 2021 - pubs.aip.org
Recent advances in droplet microfluidics have led to the fabrication of versatile vesicles with
a structure that mimics the cellular membrane. These artificial cell-like vesicles including …

Capturing coacervate formation and protein partition by molecular dynamics simulation

Y Liu, X Wang, Z Wan, T Ngai, YLS Tse - Chemical Science, 2023 - pubs.rsc.org
Biomolecules localize and function in microenvironments where their local concentration,
spatial organization, and biochemical reactivity are regulated. To compartmentalize and …

Connecting primitive phase separation to biotechnology, synthetic biology, and engineering

TZ Jia, PH Wang, T Niwa, I Mamajanov - Journal of biosciences, 2021 - Springer
One aspect of the study of the origins of life focuses on how primitive chemistries assembled
into the first cells on Earth and how these primitive cells evolved into modern cells …