The timelines for developing vaccines against infectious diseases are lengthy, and often
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …

Introduction: Cholera remains a problem in developing countries and a risk for travelers.
Hypochlorhydria, blood group O, cardiac and renal disease increase the risk of developing …

Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes that aid in
protection against bacterial pathogens at mucosal surfaces through the release of …

The Vibrio cholerae lipopolysaccharide O1 antigen is a major target of bacteriophages and
the human immune system and is of critical importance for vaccine design. We used an O1 …

Vibrio cholerae is a prototypical noninvasive mucosal pathogen, yet infection generates long-
lasting protection against subsequent disease. Vibriocidal antibody responses are an …

Vibrio cholerae is a noninvasive pathogen that colonizes the small intestine and produces
cholera toxin, causing severe secretory diarrhea. Cholera results in long lasting immunity …

Background. Noroviruses are a leading cause of acute gastroenteritis worldwide. Mucosal
and cellular immune responses remain poorly understood, with most studies of noroviruses …

Sporotrichosis associated with zoonotic transmission remains a relevant public health
problem in Rio de Janeiro, Brazil, affecting a large at-risk population, which includes HIV …

Background Mucosal Associated Invariant T (MAIT) cells are innate-like T cells found in
abundance in the intestinal mucosa, and are thought to play a role in bridging the innate …

We characterized the acute B cell response in adults with cholera by analyzing the
repertoire, specificity, and functional characteristics of 138 monoclonal antibodies (MAbs) …