Obesity and cancer mechanisms: tumor microenvironment and inflammation

NM Iyengar, A Gucalp, AJ Dannenberg… - Journal of clinical …, 2016 - ascopubs.org
Purpose There is growing evidence that inflammation is a central and reversible mechanism
through which obesity promotes cancer risk and progression. Methods We review recent …

Racial disparities in triple negative breast cancer: a review of the role of biologic and non-biologic factors

O Prakash, F Hossain, D Danos, A Lassak… - Frontiers in Public …, 2020 - frontiersin.org
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that lacks
expression of the estrogen receptor (ER), progesterone receptor (PR), and human …

Molecular mechanisms of cancer development in obesity

MJ Khandekar, P Cohen, BM Spiegelman - Nature Reviews Cancer, 2011 - nature.com
The increasing incidence of obesity and its co-morbid conditions poses a great challenge to
global health. In addition to cardiovascular disease and diabetes, epidemiological data …

Diabetes and cancer: two diseases with obesity as a common risk factor

SK Garg, H Maurer, K Reed… - Diabetes, Obesity and …, 2014 - Wiley Online Library
There is a growing body of evidence to support a connection between diabetes
(predominantly type 2), obesity and cancer. Multiple meta‐analyses of epidemiological data …

Metformin in cancer: translational challenges.

RJ Dowling, S Niraula, V Stambolic… - Journal of molecular …, 2012 - europepmc.org
The anti-diabetic drug metformin is rapidly emerging as a potential anti-cancer agent.
Metformin, effective in treating type 2 diabetes and the insulin resistance syndromes …

Obesity, type 2 diabetes, and cancer: the insulin and IGF connection

DH Cohen, D LeRoith - Endocrine-related cancer, 2012 - erc.bioscientifica.com
Epidemiological studies suggest a positive association between obesity and type 2 diabetes
mellitus (T2D) with the risk of cancer and cancer-related mortality. Insulin resistance …

Prolonged nightly fasting and breast cancer prognosis

CR Marinac, SH Nelson, CI Breen, SJ Hartman… - JAMA …, 2016 - jamanetwork.com
Importance Rodent studies demonstrate that prolonged fasting during the sleep phase
positively influences carcinogenesis and metabolic processes that are putatively associated …

Systematic review and meta-analysis of the association between diabetes mellitus and incidence and mortality in breast and colorectal cancer

KMJ De Bruijn, LR Arends, BE Hansen… - Journal of British …, 2013 - academic.oup.com
Background Increasing evidence suggests that diabetes mellitus (DM) is associated with
increased cancer incidence and mortality. Several mechanisms involved in diabetes, such …

Beneficial effects of ketogenic diets for cancer patients: a realist review with focus on evidence and confirmation

RJ Klement - Medical Oncology, 2017 - Springer
Ketogenic diets (KDs) have gained popularity among patients and researchers alike due to
their putative anti-tumor mechanisms. However, the question remains which conclusions …

Systemic correlates of white adipose tissue inflammation in early-stage breast cancer

NM Iyengar, XK Zhou, A Gucalp, PG Morris… - Clinical Cancer …, 2016 - AACR
Purpose: Obesity, insulin resistance, and elevated levels of circulating proinflammatory
mediators are associated with poorer prognosis in early-stage breast cancer. To investigate …