Astrocyte Ca2+ signalling: an unexpected complexity
Astrocyte Ca2+ signalling has been proposed to link neuronal information in different spatial–
temporal dimensions to achieve a higher level of brain integration. However, some …
temporal dimensions to achieve a higher level of brain integration. However, some …
Improving data quality in neuronal population recordings
Understanding how the brain operates requires understanding how large sets of neurons
function together. Modern recording technology makes it possible to simultaneously record …
function together. Modern recording technology makes it possible to simultaneously record …
Optimization of a GCaMP calcium indicator for neural activity imaging
Genetically encoded calcium indicators (GECIs) are powerful tools for systems
neuroscience. Recent efforts in protein engineering have significantly increased the …
neuroscience. Recent efforts in protein engineering have significantly increased the …
Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics
J Akerboom, N Carreras Calderón, L Tian… - Frontiers in molecular …, 2013 - frontiersin.org
Genetically encoded calcium indicators (GECIs) are powerful tools for systems
neuroscience. Here we describe red, single-wavelength GECIs,“RCaMPs,” engineered from …
neuroscience. Here we describe red, single-wavelength GECIs,“RCaMPs,” engineered from …
Primary cilia are specialized calcium signalling organelles
M Delling, PG DeCaen, JF Doerner, S Febvay… - Nature, 2013 - nature.com
Primary cilia are solitary, non-motile extensions of the centriole found on nearly all nucleated
eukaryotic cells between cell divisions. Only∼ 200–300 nm in diameter and a few …
eukaryotic cells between cell divisions. Only∼ 200–300 nm in diameter and a few …
A comparison of neuronal population dynamics measured with calcium imaging and electrophysiology
Calcium imaging with fluorescent protein sensors is widely used to record activity in
neuronal populations. The transform between neural activity and calcium-related …
neuronal populations. The transform between neural activity and calcium-related …
The autism-associated gene Scn2a contributes to dendritic excitability and synaptic function in the prefrontal cortex
Autism spectrum disorder (ASD) is strongly associated with de novo gene mutations. One of
the most commonly affected genes is SCN2A. ASD-associated SCN2A mutations impair the …
the most commonly affected genes is SCN2A. ASD-associated SCN2A mutations impair the …
Local Ca2+ detection and modulation of synaptic release by astrocytes
Astrocytes communicate with synapses by means of intracellular calcium ([Ca2+] i)
elevations, but local calcium dynamics in astrocytic processes have never been thoroughly …
elevations, but local calcium dynamics in astrocytic processes have never been thoroughly …
Principles of two-photon excitation microscopy and its applications to neuroscience
The brain is complex and dynamic. The spatial scales of interest to the neurobiologist range
from individual synapses (∼ 1 μm) to neural circuits (centimeters); the timescales range from …
from individual synapses (∼ 1 μm) to neural circuits (centimeters); the timescales range from …
Microdomains of Intracellular Ca2+: Molecular Determinants and Functional Consequences
Calcium ions are ubiquitous and versatile signaling molecules, capable of decoding a
variety of extracellular stimuli (hormones, neurotransmitters, growth factors, etc.) into …
variety of extracellular stimuli (hormones, neurotransmitters, growth factors, etc.) into …