Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

Drug discovery has traditionally focused on using libraries of small molecules to identify
therapeutic drugs, but new modalities, especially libraries of genetically encoded cyclic …

Rapid advancements in genomics have brought a better understanding of molecular
mechanisms for various pathologies and identified a number of highly attractive target …

Molecules that covalently bind macromolecular targets have found widespread applications
as activity-based probes and as irreversibly binding drugs. However, the general reactivity of …

Conspectus Cyclic peptides can bind to protein targets with high affinities and selectivities,
which makes them an attractive modality for the development of research reagents and …

The function of the fibrinolytic system was first identified to dissolve fibrin to maintain
vascular patency. Connections between the fibrinolytic system and many other physiological …

Multicyclic peptides with stable 3D structures are a kind of novel and promising peptide
formats for drug design and discovery as they have the potential to combine the best …

Efficient and site‐specific modification of native peptides and proteins is desirable for
synthesizing antibody‐drug conjugates as well as for constructing chemically modified …

Macrocyclic peptides are an emerging class of therapeutics that can modulate protein–
protein interactions. In contrast to the heavily automated high-throughput screening systems …

Conserved cysteine frameworks are essential components of disulfide-rich peptides (DRPs),
which dominantly define the structural diversity of both naturally occurring and de novo …