Ketamine, a racemic mixture consisting of (S)-and (R)-ketamine, has been in clinical use
since 1970. Although best characterized for its dissociative anesthetic properties, ketamine …

Clinical studies have demonstrated that a single sub-anesthetic dose of the dissociative
anesthetic ketamine induces rapid and sustained antidepressant actions. Although this …

Ketamine is a phencyclidine derivative, which functions primarily as an antagonist of the N-
methyl-d-aspartate receptor. It has no affinity for gamma-aminobutyric acid receptors in the …

Background Liver cancer ranks the top four malignant cancer type worldwide, which needs
effective and safe treatment. Ferroptosis is a novel form of regulated cell death driven by iron …

In this experimental randomized placebo-controlled 4-way crossover trial, we explored the
analgesic effects of inhaled pharmaceutical-grade cannabis in 20 chronic pain patients with …

This paper introduces a new construct, the 'pivotal mental state', which is defined as a hyper-
plastic state aiding rapid and deep learning that can mediate psychological transformation …

Despite the absence of responsiveness during anesthesia, conscious experience may
persist. However, reliable, easily acquirable and interpretable neurophysiological markers of …

For more than 50 years, ketamine has proven to be a safe anesthetic drug with potent
analgesic properties. The active enantiomer is S (+)‐ketamine. Ketamine is mostly …

The anaesthetic ketamine is used to treat various chronic pain syndromes, especially those
that have a neuropathic component. Low dose ketamine produces strong analgesia in …

Access to cannabis and cannabinoid products is increasing worldwide for recreational and
medicinal use. Two primary compounds within cannabis plant matter, Δ 9 …