Patients with inflammatory bowel disease (IBD) are at increased risk of developing
colorectal cancer (CRC), despite decreases in CRC incidence in recent years. Chronic …

The natural mammalian polyamines putrescine, spermidine and spermine are essential for
both normal and neoplastic cell function and replication. Dysregulation of metabolism of …

The tumor microenvironment (TME) influences cancer progression and therapy response.
Therefore, understanding what regulates the TME immune compartment is vital. Here we …

Recognition of the fact that bacterial biofilm may play a role in the pathogenesis of disease
has led to an increased focus on identifying diseases that may be biofilm-related. Biofilm …

Colorectal cancer (CRC) is a heterogeneous disease of the intestinal epithelium that is
characterized by the accumulation of mutations and a dysregulated immune response. Up to …

Inflammation predisposes to the development of cancer and promotes all stages of
tumorigenesis. Cancer cells, as well as surrounding stromal and inflammatory cells, engage …

The gut microbiome plays an important role in human health and influences the
development of chronic diseases ranging from metabolic disease to gastrointestinal …

Microbial dysbiosis is a colorectal cancer (CRC) hallmark and contributes to inflammation,
tumor growth, and therapy response. Gut microbes signal via metabolites, but how the …

Oncogenesis is associated with intestinal dysbiosis, and stool shotgun metagenomic
sequencing in individuals with this condition might constitute a non-invasive approach for …

Microorganisms colonize various ecological niches in the human habitat, as they do in
nature. Predominant forms of multicellular communities called biofilms colonize human …