The cytokine network involved in the host immune response to periodontitis

W Pan, Q Wang, Q Chen - International journal of oral science, 2019 - nature.com
Periodontitis is an inflammatory disease involving the destruction of both soft and hard tissue
in the periodontal region. Although dysbiosis of the local microbial community initiates local …

The immunobiology of the interleukin-12 family: room for discovery

EDT Wojno, CA Hunter, JS Stumhofer - Immunity, 2019 - cell.com
The discovery of interleukin (IL)-6 and its receptor subunits provided a foundation to
understand the biology of a group of related cytokines: IL-12, IL-23, and IL-27. These family …

Extraction, Purification, Structural Characteristics, Biological Activities and Pharmacological Applications of Acemannan, a Polysaccharide from Aloe vera: A Review

C Liu, Y Cui, F Pi, Y Cheng, Y Guo, H Qian - Molecules, 2019 - mdpi.com
Aloe vera is a medicinal plant species of the genus Aloe with a long history of usage around
the world. Acemannan, considered one of the main bioactive polysaccharides of Aloe vera …

Inflammatory bowel disease therapeutics: A focus on probiotic engineering

J Mishra, M Stubbs, L Kuang, N Vara… - Mediators of …, 2022 - Wiley Online Library
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of gastrointestinal (GI)
tract with dysregulated mucosal immune functions and disturbed commensal ecosystem of …

Could IL-25 be a potential therapeutic target for intestinal inflammatory diseases?

J Chen, Y Wang, L Shen, Y Xiu, B Wang - Cytokine & Growth Factor …, 2023 - Elsevier
As a member of the IL-17 cytokine family, IL-25 (also called IL-17E) induces and sustains
type 2 immunity. IL-25, which is mainly produced by intestinal epithelial cells, has been …

Research progress of interleukin-27 in inflammatory bowel disease

Q Wang, F Chen, Y Peng, X Yi, Y He… - Inflammatory Bowel …, 2024 - academic.oup.com
Inflammatory bowel disease (IBD) can be identified as an inflammatory disorder in the
intestine, being characterized by maladjusted immune responses and chronic inflammation …

[HTML][HTML] Oral delivery of a functional algal-expressed TGF-β mimic halts colitis in a murine DSS model

DJ Smyth, B Ren, MPJ White, C McManus… - Journal of …, 2021 - Elsevier
Inflammatory bowel disease (IBD) is a set of immunological disorders which can generate
chronic pain and fatigue associated with the inflammatory symptoms. The treatment of IBD …

Interleukin 27 is a novel cytokine with anti-inflammatory effects against spondyloarthritis through the suppression of Th17 responses

Q Jouhault, B Cherqaoui, A Jobart-Malfait… - Frontiers in …, 2023 - frontiersin.org
Introduction Spondylarthritis (SpA) development in HLA-B27/human β2-microglobulin
transgenic rat (B27-rat) is correlated with altered conventional dendritic cell (cDC) function …

Lactic acid bacteria for delivery of endogenous or engineered therapeutic molecules

PA Bron, M Kleerebezem - Frontiers in Microbiology, 2018 - frontiersin.org
Food-grade lactic acid bacteria (LAB) are considered suitable vehicles for the production
and/or delivery of health promoting or therapeutic, bioactive molecules. The molecules …

A single administration of human adipose tissue-derived mesenchymal stromal cells (MSC) induces durable and sustained long-term regulation of inflammatory …

VBF Alves, BC de Sousa, MTC Fonseca… - Clinical & …, 2019 - academic.oup.com
Current therapies for inflammatory bowel diseases (IBD) are aimed at controlling the
exacerbated response in the gut, but no treatment is fully effective for many refractory …