Neurodegenerative disorders, including Alzheimer's disease, are associated with
microgliosis. Microglia have long been considered to have detrimental roles in Alzheimer's …

TREM2 is an innate immune receptor expressed by microglia in the adult brain. Genetic
variation in the TREM2 gene has been implicated in risk for Alzheimer's disease and …

TREM2 is a membrane receptor solely expressed on microglia in normal brain. In this review
we outline recent advances in TREM2 biology and its implications for microglial function …

The single nucleotide polymorphisms rs35349669 and rs10933431 within Inositol
Polyphosphate-5-Phosphatase D (INPP5D) are strongly associated with Alzheimer's …

Determining whether the RNA isoforms from medically relevant genes have distinct
functions could facilitate direct targeting of RNA isoforms for disease treatment. Here, as a …

Due to alternative splicing, human protein-coding genes average over eight RNA isoforms,
resulting in nearly four distinct protein coding sequences per gene. Long-read RNAseq …

Genetic variants in TREM2, a microglia-related gene, are well-known risk factors for
Alzheimer's disease (AD). Here, we report that TREM2 originates from circular RNAs …

The role of myeloid cells (granulocytes and monocytes) in neurodegeneration and
neurodegenerative disorders (NDD) is indisputable. Here we discuss the roles of myeloid …

Loss-of-function variants in the triggering receptor expressed on myeloid cells 2 (TREM2)
are responsible for a spectrum of neurodegenerative disorders. In the homozygous state …

Introduction Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the
central nervous system (CNS). Current therapies primarily target the inflammatory …