Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions

MD Roberts, JJ McCarthy… - Physiological …, 2023 - journals.physiology.org
Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

[HTML][HTML] Stimuli and sensors that initiate skeletal muscle hypertrophy following resistance exercise

H Wackerhage, BJ Schoenfeld… - Journal of applied …, 2019 - journals.physiology.org
One of the most striking adaptations to exercise is the skeletal muscle hypertrophy that
occurs in response to resistance exercise. A large body of work shows that a mammalian …

Integrin signaling: linking mechanical stimulation to skeletal muscle hypertrophy

MD Boppart, ZS Mahmassani - American Journal of …, 2019 - journals.physiology.org
The α7β1-integrin is a transmembrane adhesion protein that connects laminin in the
extracellular matrix (ECM) with actin in skeletal muscle fibers. The α7β1-integrin is highly …

Implementing ultrasound imaging for the assessment of muscle and tendon properties in elite sports: Practical aspects, methodological considerations and future …

F Sarto, J Spörri, DP Fitze, JI Quinlan, MV Narici… - Sports Medicine, 2021 - Springer
Ultrasound (US) imaging has been widely used in both research and clinical settings to
evaluate the morphological and mechanical properties of muscle and tendon. In elite sports …

Comparative transcriptome and methylome analysis in human skeletal muscle anabolism, hypertrophy and epigenetic memory

DC Turner, RA Seaborne, AP Sharples - Scientific reports, 2019 - nature.com
Transcriptome wide changes in human skeletal muscle after acute (anabolic) and chronic
resistance exercise (RE) induced hypertrophy have been extensively determined in the …

Ultrasound-derived biceps femoris long-head fascicle length: extrapolation pitfalls

MV Franchi, DP Fitze, BJ Raiteri, D Hahn… - Medicine and science in …, 2020 - zora.uzh.ch
PURPOSE To compare biceps femoris long-head (BFlh) fascicle lengths (Lfs) obtained with
different ultrasound-based approaches: 1) single ultrasound images and linear Lf …

[HTML][HTML] Biceps femoris long head sarcomere and fascicle length adaptations after 3 weeks of eccentric exercise training

PA Pincheira, MA Boswell, MV Franchi, SL Delp… - Journal of sport and …, 2022 - Elsevier
Background Eccentric exercise increases muscle fascicle lengths; however, the
mechanisms behind this adaptation are still unknown. This study aimed to determine …

Physiological differences between low versus high skeletal muscle hypertrophic responders to resistance exercise training: current perspectives and future research …

MD Roberts, CT Haun, CB Mobley… - Frontiers in …, 2018 - frontiersin.org
Numerous reports suggest there are low and high skeletal muscle hypertrophic responders
following weeks to months of structured resistance exercise training (referred to as low and …

Muscle and tendon adaptations to moderate load eccentric vs. concentric resistance exercise in young and older males

JI Quinlan, MV Franchi, N Gharahdaghi, F Badiali… - GeroScience, 2021 - Springer
Resistance exercise training (RET) is well-known to counteract negative age-related
changes in both muscle and tendon tissue. Traditional RET consists of both concentric …

What makes long-term resistance-trained individuals so strong? A comparison of skeletal muscle morphology, architecture, and joint mechanics

TM Maden-Wilkinson, TG Balshaw… - Journal of applied …, 2020 - journals.physiology.org
The greater muscular strength of long-term resistance-trained (LTT) individuals is often
attributed to hypertrophy, but the role of other factors, notably maximum voluntary specific …