The cell membrane, the boundary that separates living cells from their environment, has
been the subject of study for over a century. The fluid-mosaic model of Singer and Nicolson …

This year celebrates the 50th anniversary of the Singer-Nicolson fluid mosaic model for
biological membranes. The next level of sophistication we have achieved for understanding …

Several groups have recently reported evidence for the emergence of domains in cell
plasma membranes when membrane proteins are organized by ligand binding or assembly …

The plasma membrane serves as the primary barrier between the cell's interior and its
external surroundings, which places it at the forefront of intercellular communication …

Cholera toxin B-subunit (CTxB) has emerged as one of the most widely utilized tools in
membrane biology and biophysics. CTxB is a homopentameric stable protein that binds …

Two very polarized views exist for understanding the cellular plasma membrane (PM). For
some, it is the simple fluid described by the original Singer–Nicolson fluid mosaic model. For …

The language of biology at the scale of the cell is constituted of alphabets represented by
biomolecules. These are stitched together in a variety of ways to create meaning. We argue …

Peripheral membrane proteins (PMPs) can reversibly and specifically bind to biological
membranes to carry out functions such as cell signalling, enzymatic activity, or membrane …

The spatiotemporal organization of proteins and lipids on the cell surface has direct
functional consequences for signaling, sorting, and endocytosis. Earlier studies have shown …

The plasma membrane (PM) is a highly heterogenous structure intertwined with the cortical
actin cytoskeleton and extracellular matrix. This complex architecture makes it difficult to …