Recent advances in the field of de novo protein design are examined. The data are
examined with respect to the hypothesis that most designed proteins exhibit characteristics …

Ion conduction and selectivity properties of KcsA, a bacterial ion channel of known structure,
were studied in a planar lipid bilayer system at the single-channel level. Selectivity …

Magainin2 is a 23-residue antibiotic peptide that disrupts the ionic gradient across certain
cellmembranes. Two-dimensional 1H NMR spectroscopy was used to investigate the …

Although immune checkpoint blockers have yielded significant clinical benefits in patients
with different malignancies, the efficacy of these therapies is still limited. Here, we show that …

Polypeptides composed of 30 amino acid residues or less typically do not adoptwell-defined
conformations in aqueous solution; rather they adopt an ensemble of energetically similar …

The three-dimensional structure of the channel-forming trans-membrane domain of virus
protein “u”(Vpu) of HIV-1 was determined by NMR spectroscopy in micelle and bilayer …

Peptides may be synthesized with sequences corresponding to putative transmembrane
domains and/or pore-lining regions that are deduced from the primary structures of ion …

We have recently adopted a “minimalist” approach to protein design. 1 As applied to the
analysis of natural proteins, this approach involves two steps: first, the structural basis for a …

Peptide-based packaging systems show great potential as safer drug delivery systems. They
overcome problems associated with lipid-based or viral delivery systems, vis-a-vis stability …

Ion channel proteins provide efficient and selective conduits for the transmission of ions
across biological membranes. Previously, we prepared a number of-helical peptide models …