Changes in aging bone that lead to osteoporosis are mediated at multiple levels, including
hormonal alterations, skeletal unloading, and accumulation of senescent cells. This …

Since the discovery in 1993 of the first small silencing RNA, a dizzying number of small RNA
classes have been identified, including microRNAs (miRNAs), small interfering RNAs …

In recent years, microRNAs (miRNAs) have been identified as mediators of tumour
suppression and stress responses exerted by the p53 tumour suppressor. p53-regulated …

MicroRNAs (miRNAs) have emerged as key post-transcriptional regulators of gene
expression, involved in diverse physiological and pathological processes. Although miRNAs …

MicroRNAs (miRNAs) are a class of short non-coding RNAs that bind mRNAs through partial
base-pair complementarity with their target genes, resulting in post-transcriptional …

R-loops, which consist of a DNA-RNA hybrid and a displaced DNA strand, are known to
threaten genome integrity. To counteract this, different mechanisms suppress R-loop …

Although microRNAs (miRNAs) are key regulators of gene expression, little is known of their
overall persistence in the cell following processing. Characterization of such persistence is …

Senescence is a cellular program that irreversibly arrests the proliferation of damaged cells
and induces the secretion of the inflammatory mediators IL-6 and IL-8 which are part of a …

Aberrant expression of microRNAs (miRNAs) and the enzymes that control their processing
have been reported in multiple biological processes including primary and metastatic …

Sequencing of small RNA cDNA libraries is an important tool for the discovery of new RNAs
and the analysis of their mutational status as well as expression changes across samples. It …