Biocatalysis has an enormous impact on chemical synthesis. The waves in which
biocatalysis has developed, and in doing so changed our perception of what organic …

The application of chalcogenonium salts in organic synthesis has grown enormously in the
past decades since the discovery of the methyltransferase enzyme cofactor S-adenosyl-L …

Late‐stage methylation is a key technology in the development of pharmaceutical
compounds. Methyltransferase biocatalysis may provide powerful options to insert methyl …

Methods for regioselective N‐methylation and‐alkylation of unsaturated heterocycles with
“off the shelf” reagents are highly sought‐after. This reaction could drastically simplify …

Strategic replacement of protons with fluorine atoms or functional groups with fluorine‐
containing fragments has proven a powerful strategy to optimize the activity of therapeutic …

Methylation, a widely occurring natural modification serving diverse regulatory and structural
functions, is carried out by a myriad of S-adenosyl-l-methionine (AdoMet)-dependent …

Methyltransferases (MTases) play an important role in the functioning of living systems,
catalyzing the methylation reactions of DNA, RNA, proteins, and small molecules, including …

Therapeutic enzymes present excellent opportunities for the treatment of human disease,
modulation of metabolic pathways and system detoxification. However, current use of …

S‐Adenosylmethionine (SAM) is an enzyme cofactor involved in methylation, aminopropyl
transfer, and radical reactions. This versatility renders SAM‐dependent enzymes of great …

Halide methyltransferases (HMTs) enable the enzymatic synthesis of S‐adenosyl‐l‐
methionine (SAM) from S‐adenosyl‐l‐homocysteine (SAH) and methyl iodide …