Sepsis is a common condition that is associated with unacceptably high mortality and, for
many of those who survive, long-term morbidity. Increased awareness of the condition …

In patients with acute circulatory failure, the decision to give fluids or not should not be taken
lightly. The risk of overzealous fluid administration has been clearly established. Moreover …

Objective Circulatory shock is a life-threatening syndrome resulting in multiorgan failure and
a high mortality rate. The aim of this consensus is to provide support to the bedside clinician …

Background: Sepsis is associated with generalised endothelial injury and capillary leak and
has traditionally been treated with large volume fluid resuscitation. Some patients with …

Purpose The optimal strategy of fluid resuscitation in the early hours of severe sepsis and
septic shock is controversial, with both an aggressive and conservative approach being …

Objective: To provide an update to the “Surviving Sepsis Campaign Guidelines for
Management of Severe Sepsis and Septic Shock,” last published in 2008. Design: A …

Despite an increasing incidence of acute kidney injury in both high-income and low-income
countries and growing insight into the causes and mechanisms of disease, few preventive …

Purpose We performed a systematic review and meta-analysis of studies investigating the
passive leg raising (PLR)-induced changes in cardiac output (CO) and in arterial pulse …

Importance Fluid overload occurring as a consequence of overly aggressive fluid
resuscitation may adversely affect outcome in hemodynamically unstable critically ill …

Background: Despite a previous meta-analysis that concluded that central venous pressure
should not be used to make clinical decisions regarding fluid management, central venous …