Frontiers of MicroRNA signature in non-small cell lung cancer

X Zhu, M Kudo, X Huang, H Sui, H Tian… - Frontiers in Cell and …, 2021 - frontiersin.org
Lung cancer is the leading cause of cancer-related deaths worldwide and non-small cell
lung cancer (NSCLC) accounts for more than 80% of all lung cancer cases. Recent …

Beyond tumor suppression: senescence in cancer stemness and tumor dormancy

F Triana-Martínez, MI Loza, E Domínguez - Cells, 2020 - mdpi.com
Here, we provide an overview of the importance of cellular fate in cancer as a group of
diseases of abnormal cell growth. Tumor development and progression is a highly dynamic …

Emergence of a high-plasticity cell state during lung cancer evolution

ND Marjanovic, M Hofree, JE Chan, D Canner, K Wu… - Cancer cell, 2020 - cell.com
Tumor evolution from a single cell into a malignant, heterogeneous tissue remains poorly
understood. Here, we profile single-cell transcriptomes of genetically engineered mouse …

WNT signaling–lung cancer is no exception

J Rapp, L Jaromi, K Kvell, G Miskei, JE Pongracz - Respiratory research, 2017 - Springer
Since the initial discovery of the oncogenic activity of WNT ligands our understanding of the
complex roles for WNT signaling pathways in lung cancers has increased substantially. In …

H19 promotes non‐small‐cell lung cancer (NSCLC) development through STAT3 signaling via sponging miR‐17

Z Huang, W Lei, HB Hu, H Zhang… - Journal of cellular …, 2018 - Wiley Online Library
LncRNAs can exhibit crucial roles in the development of multiple cancers, including non‐
small cell lung cancer (NSCLC). Currently, we investigated the role of lncRNA H19 in …

MiRNA-based therapeutics for lung cancer

M Wu, G Wang, W Tian, Y Deng… - Current pharmaceutical …, 2017 - ingentaconnect.com
Background: miRNA, a small non-coding RNA molecule containing about 22 nucleotides,
functions in RNA silencing and post-transcriptional regulation of gene expression. With …

miR-19 targeting of GSK3β mediates sulforaphane suppression of lung cancer stem cells

J Zhu, S Wang, Y Chen, X Li, Y Jiang, X Yang… - The Journal of nutritional …, 2017 - Elsevier
Cancer stem cells (CSCs) play a central role in the development of cancer. The canonical
Wnt/β-catenin pathway is critical for maintaining stemness of CSCs. Phytochemicals from …

[HTML][HTML] MiR-93 promotes tumorigenesis and metastasis of non-small cell lung cancer cells by activating the PI3K/Akt pathway via inhibition of LKB1/PTEN/CDKN1A

C Li, J Lyu, QH Meng - Journal of Cancer, 2017 - ncbi.nlm.nih.gov
Background: Non-small cell lung cancer (NSCLC) accounts for approximately 85% of
clinical lung cancer cases. MicroRNA-93 (miR-93) is an oncomiR in many types of human …

Maresin-1 and its receptors RORα/LGR6 as potential therapeutic target for respiratory diseases

M Zhao, C Li, J Zhang, Z Yin, Z Zheng, J Wan… - Pharmacological …, 2022 - Elsevier
Maresin-1 is one of the representative specialized pro-resolving mediators that has shown
beneficial effects in inflammatory disease models. Recently, two distinct types of receptor …

Silencing LGR6 attenuates stemness and chemoresistance via inhibiting Wnt/β-catenin signaling in ovarian cancer

X Ruan, A Liu, M Zhong, J Wei, W Zhang… - Molecular Therapy …, 2019 - cell.com
Leucine-rich-repeat-containing G protein-coupled receptors (LGRs) have been widely found
to be implicated with development and progression in multiple cancer types. However, the …