The mixed-lineage leukemia 1 (MLL1) gene (now renamed Lysine [K]-specific
MethylTransferase 2A or KMT2A) on chromosome 11q23 is disrupted in a unique group of …

Nucleoside, nucleotide, and base analogs have been in the clinic for decades to treat both
viral pathogens and neoplasms. More than 20% of patients on anticancer chemotherapy …

Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA
modification, histone modification, RNA modification, chromatin remodeling, and non-coding …

Motivation Mining drug–disease association and related interactions are essential for
developing in silico drug repurposing (DR) methods and understanding underlying …

The MLL (mixed-lineage leukemia) gene, located on chromosome 11q23, is involved in
chromosomal translocations in a subtype of acute leukemia, which represents approximately …

Carcinogenesis as well as cancer progression result from genetic and epigenetic changes
of the genome that leads to dysregulation of transcriptional activity of genes. Epigenetic …

Ovarian cancer is currently the most life-threatening type of gynecological malignancy with
limited treatment options. Therefore, improved targeted therapies are required to combat …

Highlights•This review mainly summarizes the anti-cancer effects of adenosine analogues in
market and clinical trials.•This review describes the anti-cancer strategies and mechanisms …

Background/Aim: Sporadic breast cancer is frequently associated with aberrant DNA
methylation patterns that are reversible and responsive to environmental factors, including …

Cytotoxic adenosine analogues were among the earliest chemotherapeutic agents utilised
in cancer treatment. Cordycepin, a natural derivative of adenosine discovered in the fungus …