Transcriptional architecture of the mammalian circadian clock

JS Takahashi - Nature Reviews Genetics, 2017 - nature.com
Circadian clocks are endogenous oscillators that control 24-hour physiological and
behavioural processes in organisms. These cell-autonomous clocks are composed of a …

Molecular architecture of the mammalian circadian clock

CL Partch, CB Green, JS Takahashi - Trends in cell biology, 2014 - cell.com
Circadian clocks coordinate physiology and behavior with the 24h solar day to provide
temporal homeostasis with the external environment. The molecular clocks that drive these …

Mutation of the human circadian clock gene CRY1 in familial delayed sleep phase disorder

A Patke, PJ Murphy, OE Onat, AC Krieger, T Özçelik… - Cell, 2017 - cell.com
Patterns of daily human activity are controlled by an intrinsic circadian clock that promotes∼
24 hr rhythms in many behavioral and physiological processes. This system is altered in …

Molecular components of the Mammalian circadian clock

ED Buhr, JS Takahashi - Circadian clocks, 2013 - Springer
Mammals synchronize their circadian activity primarily to the cycles of light and darkness in
the environment. This is achieved by ocular photoreception relaying signals to the …

Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

H Cho, X Zhao, M Hatori, RT Yu, GD Barish, MT Lam… - Nature, 2012 - nature.com
The circadian clock acts at the genomic level to coordinate internal behavioural and
physiological rhythms via the CLOCK–BMAL1 transcriptional heterodimer. Although the …

Whole genome analysis of a schistosomiasis-transmitting freshwater snail

CM Adema, LDW Hillier, CS Jones, ES Loker… - Nature …, 2017 - nature.com
Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma
mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global …

Identification of small molecule activators of cryptochrome

T Hirota, JW Lee, PC St. John, M Sawa, K Iwaisako… - Science, 2012 - science.org
Impairment of the circadian clock has been associated with numerous disorders, including
metabolic disease. Although small molecules that modulate clock function might offer …

Metabolic rivalry: circadian homeostasis and tumorigenesis

K Kinouchi, P Sassone-Corsi - Nature Reviews Cancer, 2020 - nature.com
Circadian rhythms govern a large array of physiological and metabolic functions.
Perturbations of the daily cycle have been linked to elevated risk of developing cancer as …

The clock gene circuit in Arabidopsis includes a repressilator with additional feedback loops

A Pokhilko, AP Fernández, KD Edwards… - Molecular systems …, 2012 - embopress.org
Circadian clocks synchronise biological processes with the day/night cycle, using molecular
mechanisms that include interlocked, transcriptional feedback loops. Recent experiments …

CircaDB: a database of mammalian circadian gene expression profiles

A Pizarro, K Hayer, NF Lahens… - Nucleic acids …, 2012 - academic.oup.com
Abstract CircaDB (http://circadb. org) is a new database of circadian transcriptional profiles
from time course expression experiments from mice and humans. Each transcript's …