The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome
biogenesis is the process that generates ribosomes and plays an essential role in cell …

In higher eukaryotes, fine-tuned activation of protein-coding genes and many non-coding
RNAs pivots around the regulated activity of RNA polymerase II (Pol II). The Integrator …

Transfer RNAs (tRNAs) have been historically viewed as non-dynamic adaptors that decode
the genetic code into proteins. Recent work has uncovered dynamic regulatory roles for …

Chromatin immunoprecipitation (ChIP) followed by high-throughput DNA sequencing (ChIP-
seq) has become a valuable and widely used approach for mapping the genomic location of …

Chromatin profiling has emerged as a powerful means of genome annotation and detection
of regulatory activity. The approach is especially well suited to the characterization of non …

A dichotomous choice for metazoan cells is between proliferation and differentiation.
Measuring tRNA pools in various cell types, we found two distinct subsets, one that is …

Reprogramming of cellular metabolism is a key event during tumorigenesis. Despite being
known for decades (Warburg effect), the molecular mechanisms regulating this switch …

DNA methylation was first described almost a century ago; however, the rules governing its
establishment and maintenance remain elusive. Here we present data demonstrating that …

This review deals first with general questions: how to evaluate transcription inhibition,
describe changes in nuclear structure due to transcription inhibition, report on genes that are …

The human body contains thousands of unique cell types, each with specialized functions.
Cell identity is governed in large part by gene transcription programs, which are determined …