As a member of the nuclear receptor (NR) superfamily, pregnane X receptor (PXR; NR1I2) is
a ligand-activated transcription factor that plays a crucial role in the metabolism of …

Abstract Pregnane X receptor (PXR, NR1I2) is a prototypical member of the nuclear receptor
superfamily. PXR can be activated by both endobiotics and xenobiotics. As a key xenobiotic …

The pregnane X receptor (PXR) is a kind of orphan nuclear receptor activated by a series of
ligands. Environmental endocrine disruptors (EEDs) are a wide class of molecules present …

Pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are two nuclear
receptors that are well-known for their roles in xenobiotic detoxification by regulating the …

Pregnane X receptor (PXR) has been reported to regulate glycolipid metabolism. The
dysfunction of intestinal barrier contributes to metabolic disorders. However, the role of …

Pregnane X receptor (PXR), constitutive androstane receptor (CAR), aryl hydrocarbon
receptor (AHR) and peroxisome proliferator‐activated receptor α (PPAR α) are ligand …

Drug-induced hyperglycemia/diabetes is a global issue. Some drugs induce hyperglycemia
by activating the pregnane X receptor (PXR), but the mechanism is unclear. Here, we report …

Nuclear pregnane X receptor (PXR, NR1I2) and constitutive active/androstane receptor
(CAR, NR1I3) are nuclear receptors characterized in 1998 by their capability to respond to …

Renal fibrosis is a common pathological feature of chronic kidney disease (CKD) with
various etiologies, which seriously affects the structure and function of the kidney. Pregnane …

Pregnane x receptor (PXR) as a nuclear receptor is well-established in drug metabolism,
however, it has pleiotropic functions in regulating inflammatory responses, glucose …