Genomic and precision medicine research has afforded notable advances in human cancer
treatment, yet applicability to other species remains uncertain. Through whole-exome and …

Simple Summary This review deals with the general notion of EMT and the main factors
regulating this process, including transcription factors, microRNAs, reactive oxygen species …

Simple Summary Prostate cancer (PC) is one of the main types of cancer that affects the
male population worldwide. In recent decades, there has been a significant evolution in the …

Melanoma progression is associated with the epithelial-mesenchymal transition (EMT) when
tumor cells reduce E-cadherin and increase N-cadherin expression resulting in an escape …

Abstract The PTEN, AR, MDM2 and p53 protein network plays a central role in the
development of many human cancers, thus eliciting the development of targeted cancer …

An unusual variant of prostate adenocarcinoma (PC) expressing nuclear p63 in secretory
cells instead of the typical basal expression has been reported in men. Nevertheless, the …

Canine prostate adenocarcinoma (PAC) and transitional cell carcinoma (TCC) of prostate
and urinary bladder are highly invasive and metastatic tumors of closely neighbored organs …

Canine carcinomas have been considered natural models for human diseases; however,
the genomic profile of canine prostate cancers (PCs) has not been explored. In this study, 14 …

Background c-KIT expression has been related to bone metastasis in human prostate
cancer, but whether c-KIT expression can be similarly classified in canine prostatic tissue is …

E-cadherin, a glycoprotein involved in cell-cell adhesion, has a pivotal role in epithelial-
mesenchymal transition, a process through which neoplastic epithelial cells develop an …