Protease inhibitors play crucial roles in parasite development and survival, counteracting the
potentially damaging immune responses of their vertebrate hosts. However, limited …

All living organisms require protein degradation to terminate biological processes and
remove damaged proteins. One such machine is the 20S proteasome, a specialized barrel …

BACKGROUND Schistosomiasis is a disease caused by Schistosoma. Due to its complex
life cycle, evolutionary position and sexual dimorphism, schistosomes have several …

Background The proteasome in eukaryotic cells can degrade a variety of proteins and plays
an important role in regulating the cell cycle, cell survival and apoptosis. The proteasome …

The proteasome is the key player in the cellular protein degradation machinery and is
pivotal for protein homeostasis and Schistosoma mansoni (S. mansoni) survival. Our group …

The proteasome proteolytic system is the major ATP-dependent protease in eukaryotic cells
responsible for intracellular protein turnover. Schistosoma mansoni has been reported to …

The ubiquitin-proteasome system is responsible for degradation of the majority of
intracellular proteins in eukaryotic cells. The 26S proteasome proteolytic complex is …

The proteasome is the key player in the cellular protein degradation machinery and is
pivotal for protein homeostasis and Schistosoma mansoni (S. mansoni) survival. Our group …

The proteasome is an essential multi-protein complex found within all eukaryotes. It
degrades unwanted proteins and is involved in regulating many cellular functions, including …

A esquistossomose mansônica é a segunda maior endemia parasitária do mundo em
termos de extensão das áreas endêmicas e do número de pessoas infectadas com 200 …