Advances in research on the bioactivity of alginate oligosaccharides

M Xing, Q Cao, Y Wang, H Xiao, J Zhao, Q Zhang, A Ji… - Marine drugs, 2020 - mdpi.com
Alginate is a natural polysaccharide present in various marine brown seaweeds. Alginate
oligosaccharide (AOS) is a degradation product of alginate, which has received increasing …

Dysregulated miRNAs network in the critical COVID-19: An important clue for uncontrolled immunothrombosis/thromboinflammation

SS Mortazavi-Jahromi, M Aslani - International Immunopharmacology, 2022 - Elsevier
Known as a pivotal immunohemostatic response, immunothrombosis is activated to restrict
the diffusion of pathogens. This beneficial intravascular defensive mechanism represents …

LncRNA LINC-PINT increases SOCS1 expression by sponging miR-155-5p to inhibit the activation of ERK signaling pathway in rheumatoid arthritis synovial …

J Wang, Q Zhao - International immunopharmacology, 2020 - Elsevier
Rheumatoid arthritis (RA) is a systemic and chronic autoimmune disease associated with
altered gene expression in synovial tissue. Long intergenic non-protein encoding long-chain …

Infrared light therapy relieves TLR-4 dependent hyper-inflammation of the type induced by COVID-19

B Aguida, M Pooam, M Ahmad… - … & integrative biology, 2021 - Taylor & Francis
The leading cause of mortality from COVID-19 infection is respiratory distress due to an
exaggerated host immune response, resulting in hyper-inflammation and ensuing cytokine …

Immunopharmacological effect of β‐d‐mannuronic acid (M2000), as a new immunosuppressive drug, on gene expression of miR‐155 and its target molecules …

SS Mortazavi‐Jahromi, M Aslani… - Drug Development …, 2020 - Wiley Online Library
The positive impacts of β‐d‐mannuronic acid (M2000) on the gene expression of miR‐155,
its target molecules (SOCS1 and SHIP1), and NF‐κB transcription factor were demonstrated …

The role of alginate oligosaccharide on boar semen quality: A research review

Y Zhou, Z Wei, Y Gao, H Zhang, M Schroyen - International Journal of …, 2024 - Elsevier
Alginate is the general term of a polysaccharide which is widely used in the area of
pharmaceutics and the food industry and is known for its unique biological activities …

LncRNA MIAT suppresses inflammation in LPS-induced J774A. 1 macrophages by promoting autophagy through miR-30a-5p/SOCS1 axi

L Sun, K Yang, L Wang, S Wu, D Wen, J Wang - Scientific Reports, 2024 - nature.com
Accumulated data implicate that long noncoding RNA (lncRNA) plays a pivotal role in
rheumatoid arthritis (RA), potentially serving as a competitive endogenous RNA (ceRNA) for …

Guluronic acid can inhibit copper (II) and amyloid− β peptide coordination and reduce copper-related reactive oxygen species formation associated with Alzheimer's …

H Shen, Y Dou, X Wang, X Wang, F Kong… - Journal of Inorganic …, 2023 - Elsevier
Copper-related reactive oxygen species (ROS) formation can lead to neuropathologic
degradation associated with Alzheimer's disease (AD) according to amyloid cascade …

Evaluation of the effect of α-L-guluronic acid (G2013) on COX-1, COX-2 activity and gene expression for introducing this drug as a novel NSAID with …

A Mirshafiey, SS Mortazavi-Jahromi… - Recent patents on …, 2018 - ingentaconnect.com
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat the
pathological pain and inflammation through inhibition of cyclooxygenase (COX) enzyme and …

Evaluation of G2013 (α‐L‐guluronic acid) efficacy on PC‐3 cells through inhibiting the expression of inflammatory factors

Z Bagherian, A Mirshafiey… - Clinical and …, 2022 - Wiley Online Library
Given multiple treatment strategies for prostate cancer, its mortality rate is still high;
therefore, novel treatment strategies seem necessary. G2013 or α‐L‐guluronic acid is a new …