Unlocking the potential of microfluidics in mass spectrometry-based immunopeptidomics for tumor antigen discovery
The identification of tumor-specific antigens (TSAs) is critical for developing effective cancer
immunotherapies. Mass spectrometry (MS)-based immunopeptidomics has emerged as a …
immunotherapies. Mass spectrometry (MS)-based immunopeptidomics has emerged as a …
Benchmarking bioinformatics pipelines in data-independent acquisition mass spectrometry for immunopeptidomics
Immunopeptidomes are the peptide repertoires bound by the molecules encoded by the
major histocompatibility complex [human leukocyte antigen (HLA) in humans]. These HLA …
major histocompatibility complex [human leukocyte antigen (HLA) in humans]. These HLA …
New insights and approaches for analyses of immunopeptidomes
Human leucocyte antigen (HLA) molecules play a key role in health and disease by
presenting antigen to T-lymphocytes for immunosurveillance. Immunopeptidomics involves …
presenting antigen to T-lymphocytes for immunosurveillance. Immunopeptidomics involves …
Machine learning-enhanced immunopeptidomics applied to T-cell epitope discovery for COVID-19 vaccines
KA Kovalchik, DJ Hamelin, P Kubiniok… - Nature …, 2024 - nature.com
Next-generation T-cell-directed vaccines for COVID-19 focus on establishing lasting T-cell
immunity against current and emerging SARS-CoV-2 variants. Precise identification of …
immunity against current and emerging SARS-CoV-2 variants. Precise identification of …
Integrating Machine Learning-Enhanced Immunopeptidomics and SARS-CoV-2 Population-Scale Analyses Unveils Novel Antigenic Features for Next-Generation …
Next-generation T-cell-directed vaccines for COVID-19 aim to induce durable T-cell
immunity against circulating and future hypermutated SARS-CoV-2 variants. Mass …
immunity against circulating and future hypermutated SARS-CoV-2 variants. Mass …