Shortening synthetic routes to small molecule active pharmaceutical ingredients employing biocatalytic methods

S Simić, E Zukić, L Schmermund, K Faber… - Chemical …, 2021 - ACS Publications
Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …

The importance of sulfur-containing motifs in drug design and discovery

M Mustafa, JY Winum - Expert opinion on drug discovery, 2022 - Taylor & Francis
Introduction Sulfur-containing functional groups are privileged motifs that occur in various
pharmacologically effective substances and several natural products. Various functionalities …

Heterogeneous graphitic carbon nitrides in visible-light-initiated organic transformations

SK Verma, R Verma, YR Girish, F Xue, L Yan… - Green …, 2022 - pubs.rsc.org
In recent years, g-C3N4 photocatalyst-mediated organic reactions have represented an
important mode of chemical transformations and are expected to become a crucial field at …

Role of sulfur compounds in vegetable and mushroom aroma

MA Marcinkowska, HH Jeleń - Molecules, 2022 - mdpi.com
At the base of the food pyramid is vegetables, which should be consumed most often of all
food products, especially in raw and unprocessed form. Vegetables and mushrooms are rich …

Aerobic photocatalysis: oxidation of sulfides to sulfoxides

E Skolia, PL Gkizis, CG Kokotos - ChemPlusChem, 2022 - Wiley Online Library
Sulfoxides constitute one of the most important functional groups in organic chemistry found
in numerous pharmaceuticals and natural products. Sulfoxides are usually obtained from the …

How do we address neglected sulfur pharmacophores in drug discovery?

MJ Tilby, MC Willis - Expert Opinion on Drug Discovery, 2021 - Taylor & Francis
Sulfur is an ubiquitous heteroatom in medicinal chemistry [1]. Its prevalence is often credited
to its ability to exist in many oxidation states, whilst also being capable of bonding to a …

Dehydrogenative imination of low-valent sulfur compounds─ fast and scalable synthesis of sulfilimines, sulfinamidines, and sulfinimidate esters

M Klein, DL Troglauer, SR Waldvogel - JACS Au, 2023 - ACS Publications
Herein, we describe an electrochemical pathway for the synthesis of sulfilimines,
sulfoximines, sulfinamidines, and sulfinimidate esters from readily available low-valent sulfur …

Synthesis of functionalized sulfilimines via iron-catalyzed sulfur alkylation of sulfenamides with diazo compounds

X Wu, M Chen, FS He, J Wu - Green Chemistry, 2023 - pubs.rsc.org
An efficient iron-catalyzed sulfur alkylation of sulfenamides with 2, 2, 2-trifluorodiazoethane
is developed. The reaction proceeds smoothly at room temperature in an open flask …

Automated multi-objective reaction optimisation: which algorithm should I use?

P Müller, AD Clayton, J Manson, S Riley… - Reaction Chemistry & …, 2022 - pubs.rsc.org
Multi-objective optimisation algorithms (MOOAs) are, of increasing interest for the efficient
optimisation of chemical processes. However, an algorithm's performance can vary on a …

Critical role of interface design in acceleration of overall water splitting and hybrid electrolysis process: state of the art and perspectives

S Behera, S Ganguly, C Loha, B Mondal… - Energy & Fuels, 2023 - ACS Publications
Electrocatalytic water splitting to hydrogen (H2) is an ideal approach to generate renewable
energy. One of the major drawbacks is the tightly coupled kinetically sluggish and energy …