Considerable advances have been made in our understanding of age-related macular
degeneration (AMD) genetics over the past decade. The genetic associations discovered to …

Sorsby fundus dystrophy (SFD) is an autosomal dominant macular dystrophy with an
estimated prevalence of 1 in 220,000 and an onset of disease around the 4th to 6th decade …

Age-related macular degeneration (AMD) is a complex and multifactorial disease, resulting
from the interaction of environmental and genetic factors. The continuous discovery of …

One of the major causes of vision impairment among elderly people in developed nations is
age-related macular degeneration (AMD). The distinctive features of AMD are the …

Tissue inhibitor of metalloproteinase-3 (TIMP-3) is a component of the extracellular
environment, where it mediates diverse processes including matrix regulation/turnover …

Sorsby fundus dystrophy (SFD) is a rare autosomal dominant disorder with complete
penetrance affecting the macula. This is caused by a mutation in the TIMP-3. This objective …

Bruch's membrane, an extracellular matrix located between the retinal pigment epithelium
and the choroid, plays a vital role as structural and functional support to the retinal pigment …

Age-related macular degeneration (AMD) is the leading cause of blindness in the
industrialized world. AMD is associated with dysfunction and atrophy of the retinal pigment …

TIMP3 mutations are associated with early-onset macular choroidal neovascularisation for
which no treatment currently exists. CRISPR base editing, with its ability to irreversibly …

Age-related macular degeneration (AMD) is a complex disease with multiple genetic and
environmental risk factors. In the age of molecular genetics, many investigators have …