Local anesthetic systemic toxicity (LAST) is a life-threatening adverse event that may occur
after the administration of local anesthetic drugs through a variety of routes. Increasing use …

Based on findings that the cardiotoxicity infrequently observed with racemic bupivacaine
shows enantioselectivity, ie it is more pronounced with the R (+)-enantiomer, the S (−) …

In 1850, about three centuries after the conquest of Peru by Pizzaro, the Austrian von
Scherzer brought a sufficient quantum of coca leaves to Europe to permit the isolation of …

Levobupivacaine and ropivacaine, two new long-acting local anesthetics, have been
developed as an alternative to bupivacaine, after the evidence of its severe toxicity. Both of …

Two new, long-acting local anaesthetics have been developed after the evidence of
bupivacaine-related severe toxicity: levobupivacaine and ropivacaine. Both these agents …

Bupivacaine is a long-duration local anaesthetic that has remained popular within regional
and obstetric anaesthesia over three decades. Bupivacaine shows good motor/sensory …

Introduction Emergency clinicians utilize local anesthetics for a variety of procedures in the
emergency department (ED) setting. Local anesthetic systemic toxicity (LAST) is a potentially …

There is no information comparing the ability to reverse the cardiotoxic effects associated
with incremental overdosage of bupivacaine (BUP) to levobupivacaine (LBUP), ropivacaine …

The experimental use of lipid emulsion for local anesthetic toxicity was originally identified in
1998. It was then translated to clinical practice in 2006 and expanded to drugs other than …

Bupivacaine has a chiral centre and is currently available as a racemic mixture of its two
enantiomers: R (+)-bupivacaine and S (-)-bupivacaine. Preclinical studies have …