Long recognized as an important regulatory mechanism in biosignal processes, modulation
of the phosphorylation state of proteins has emerged as the most important mechanism for …

Regulation of Ca2+ in the nucleus is a debated issue, essentially due to the presence in the
envelope of the pores, which are large enough to permit the passive traffic of small …

There has been much interest in the biochemical and biophysical processes that couple
extracellular signals to alterations in gene expression. While many early events associated …

Calcium is believed to control a variety of cellular processes, often with a high degree of
spatial and temporal precision. For a cell to use Ca2+ in this manner, mechanisms must …

Previous work demonstrated the existence of phosphatidylinositol kinase and
phosphatidylinositol phosphate kinase in rat liver nuclei, with the suggestion that these …

Incubation of isolated rat liver nuclei with ATP, NAD+, and submicromolar Ca 2+
concentrations resulted in extensive DNA hydrolysis. Half-maximal activity occurred with 200 …

Secretory proteins and most membrane proteins are synthesized with a signal sequence
that is usually cleaved from the nascent polypeptide during transport into the lumen of the …

During the purification of nerve growth factor from mouse submaxillary glands by
carboxymethyl cellulose chromatography, distinct biological activities were noticed when a …

The envelope membrane of rat liver nuclei contains a P-type Ca (2+)-transporting pump,
revealed by the presence of a Ca (2+)-stimulated phosphoenzyme. The level of the nuclear …

!. Introduction in the course of evolution, eukaryotic cells have developed a concentric
porous double membrane, termed nuclear envelope, separating the nucleus from the …