This microperspective covers the most recent research outcomes of artificial intelligence (AI)
generated molecular structures from the point of view of the medicinal chemist. The main …

Nitroimidazoles based compounds remain a hot topic of research in medicinal chemistry
due to their numerous biological activities. Moreover, many clinical candidates based on this …

Metronidazole (MD) is known as a periodontitis medicine and has been widely used in
antibiotics for resistance to anaerobic bacteria, periodontal disease, and other threats. To …

In previous papers, we have reported on the high antifungal and significant antibacterial
activity against Gram-positive and Gram-negative bacteria of the water-soluble silver (I) …

Epidermal growth factor receptor (EGFR) is an important validated drug target for cancer
therapy. Some therapeutic agents targeting EGFR have been developed, however these are …

Aim Herein, the anti-parasitic activity of azoles (fluconazole and itraconazole) and 5-
nitroimdazole (metronidazole) against the brain-eating amoebae: Naegleria fowleri and …

A new series of 4-aminochloroquinoline based sulfonamides were synthesized and
evaluated for antiamoebic and antimalarial activities. Out of the eleven compounds …

Metronidazole (MTZ) is an antibacterial drug widely used for the treatment of protozoan and
anaerobic infections in humans and animals. However, its low bioavailability necessitates …

Dimetronidazole (DMZ), an veterinary antibiotic, exhibits poor photostability with only
80.38% potency remaining after exposure to illuminance of 4500 lux for 7 days. The …

Simple Summary Our previous studies demonstrated that a silver (I) nitrate complex with
metronidazole presented greater photo-stability, antimicrobial, cytotoxic and genotoxic …