The molecular principles of gene regulation by Polycomb repressive complexes
NP Blackledge, RJ Klose - Nature reviews Molecular cell biology, 2021 - nature.com
Precise control of gene expression is fundamental to cell function and development.
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …
The pausing zone and control of RNA polymerase II elongation by Spt5: Implications for the pause-release model
The pause-release model of transcription proposes that 40–100 bases from the start site
RNA Pol II pauses, followed by release into productive elongation. Pause release is …
RNA Pol II pauses, followed by release into productive elongation. Pause release is …
[HTML][HTML] NusG–Spt5 Transcription Factors: Universal, Dynamic Modulators of Gene Expression
RA Mooney, J Zhu, J Saba, R Landick - Journal of Molecular Biology, 2024 - Elsevier
The accurate and efficient biogenesis of RNA by cellular RNA polymerase (RNAP) requires
accessory factors that regulate the initiation, elongation, and termination of transcription. Of …
accessory factors that regulate the initiation, elongation, and termination of transcription. Of …
Single-molecule studies reveal branched pathways for activator-dependent assembly of RNA polymerase II pre-initiation complexes
Summary RNA polymerase II (RNA Pol II) transcription reconstituted from purified factors
suggests pre-initiation complexes (PICs) can assemble by sequential incorporation of …
suggests pre-initiation complexes (PICs) can assemble by sequential incorporation of …
Distinct patterns of RNA polymerase II and transcriptional elongation characterize mammalian genome activation
K Abe, T Schauer, ME Torres-Padilla - Cell Reports, 2022 - cell.com
How transcription is regulated as development commences is fundamental to understand
how the transcriptionally silent mature gametes are reprogrammed. The embryonic genome …
how the transcriptionally silent mature gametes are reprogrammed. The embryonic genome …
Dynamic competition between a ligand and transcription factor NusA governs riboswitch-mediated transcription regulation
Cotranscriptional RNA folding is widely assumed to influence the timely control of gene
expression, but our understanding remains limited. In bacteria, the fluoride (F−)-sensing …
expression, but our understanding remains limited. In bacteria, the fluoride (F−)-sensing …
Transcriptional activators in the early Drosophila embryo perform different kinetic roles
TT Harden, BJ Vincent, AH DePace - Cell systems, 2023 - cell.com
Combinatorial regulation of gene expression by transcription factors (TFs) may in part arise
from kinetic synergy—wherein TFs regulate different steps in the transcription cycle. Kinetic …
from kinetic synergy—wherein TFs regulate different steps in the transcription cycle. Kinetic …
Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation
Collective cell behavior contributes to all stages of cancer progression. Understanding how
collective behavior emerges through cell-cell interactions and decision-making will advance …
collective behavior emerges through cell-cell interactions and decision-making will advance …
Steady-state distributions of nascent RNA for general initiation mechanisms
J Szavits-Nossan, R Grima - Physical Review Research, 2023 - APS
Fluctuations in the number of nascent RNA accurately reflect transcriptional activity.
However, mathematical models predicting their distributions are difficult to solve analytically …
However, mathematical models predicting their distributions are difficult to solve analytically …
Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II
Previous structural studies of the initiation-elongation transition of RNA polymerase II (pol II)
transcription have relied on the use of synthetic oligonucleotides, often artificially …
transcription have relied on the use of synthetic oligonucleotides, often artificially …