This review considers the relationship between the lifespan of an individual plant and the
longevity of its component cells, tissues and organs. It begins by defining the terms …

Myriad genetic and epigenetic alterations are required to drive normal cells toward
malignant transformation. These somatic events commandeer many signaling pathways that …

Malignant cells, like all actively growing cells, must maintain their telomeres, but genetic
mechanisms responsible for telomere maintenance in tumors have only recently been …

Telomere dynamics are a critical component of both aging and cancer. Telomeres
progressively shorten in almost all dividing cells and most human cells do not express or …

The adult human heart does not regenerate significant amounts of lost tissue after injury.
Rather than making new, functional muscle, human hearts are prone to scarring and …

Telomeres, the DNA–protein structures located at the ends of chromosomes, have been
proposed to act as a biomarker of aging. In this review, the human evidence that telomere …

The role of adult mesenchymal stem cells (MSC) in tissue maintenance and regeneration
has received significant attention of late. Questions arise to what extent these cells are either …

Chromosome aberrations in human solid tumors are hallmarks of gene deregulation and
genome instability. This review summarizes current knowledge regarding aberrations …

Publisher Summary This chapter presents a discussion on the reliability theory of aging and
longevity. In reliability theory, aging is defined as a phenomenon of increasing risk of failure …

Research on mechanisms underlying fetal programming of health and disease risk has
focused primarily on processes that are specific to cell types, organs or phenotypes of …