Deregulation of protein post-translational modifications is intensively involved in the etiology
of diseases, including degenerative diseases, inflammatory injuries, and cancers …

Histone deacetylases (HDACs) are zinc-dependent deacetylases that remove acetyl groups
from lysine residues of histones or form protein complexes with other proteins for …

Class I histone deacetylases (HDACs) are closely associated with the development of a
diverse array of diseases, including cancer, neurodegenerative disorders, HIV, and …

Epilepsy is a common and severe chronic neurological disorder. Recently, post-translational
modification (PTM) mechanisms, especially protein acetylation modifications, have been …

Epilepsy remains a prevalent chronic neurological disease that is featured by aberrant,
recurrent and hypersynchronous discharge of neurons and poses a great challenge to …

Polyamine deacetylase activity was discovered more than 40 years ago, but the responsible
histone deacetylase 10 (HDAC10) was described only recently. HDAC10 is a class IIb …

Mesial temporal lobe epilepsy (MTLE) is the most common type of focal epilepsy in adults,
and hippocampal sclerosis (HS) is a frequent histopathological feature in patients with …

Abstract Histone deacetylase (HDAC) 10, a class II family, has been implicated in various
tumors and non-tumor diseases, which makes the discovery of biological functions and …

Epilepsy affects over 50 million individuals globally, making it the most prevalent chronic
and serious neurological condition. A precise therapeutic strategy is complicated by poor …

We tested a hypothesis that in silico-discovered compounds targeting traumatic brain injury
(TBI)-induced transcriptomics dysregulations will mitigate TBI-induced molecular pathology …