Pyrazole moiety is considered as the most important therapeutic agent for the treatment of
inflammation and inflammation associated cancers. Celecoxib, Ramifenazone, Rimonabant …

The current review discusses the importance of combretastatin A-4 (CA-4) as a lead
compound of microtubule targeting agents. CA-4 holds a unique place among naturally …

Two series comprising 20 novel benzenesulfonamides bearing thioureido‐linked pyrazole 8
and amino‐1, 2, 4‐thiadiazole 10 were synthesized and assayed as human carbonic …

A series of cis-restricted 3-aryl-4-(3, 4, 5-trimethoxyphenyl) pyridines as novel tubulin
polymerisation inhibitors was designed based on molecular docking. Compound 9p …

A new series of derivatives characterized by the presence of the 3, 4, 5-
trimethoxylbenzamide substituted benzofurans were synthesized and evaluated for …

Through structural optimization and ring fusion strategy, we designed a series of novel
imidazo [1, 2–a] pyrazine derivatives as potential tubulin inhibitors. These compounds …

Abstract Some novel 4-aryl-9H-carbazoles were designed as potential tubulin
polymerization inhibitors through structural optimization and bioisosteric strategy. These …

In the current study, a new series of N-acetylpyrazolines (6a-d) were designed and
synthesized from their corresponding chalcones and hydrazine hydrate in acidic medium …

Abstract A series of 3-(3′, 4′, 5′-trimethoxyphenyl)-4-substituted 1H-pyrazole and their
related 3-aryl-4-(3′, 4′, 5′-trimethoxyphenyl)-1-H-pyrazole regioisomeric derivatives …

The colchicine binding site on tubulin has been widely acknowledged as an attractive target
for anticancer drug exploitation. Here, we reported the structural optimization of the lead …