Polycystic ovary syndrome (PCOS) was hypothesized to result from functional ovarian
hyperandrogenism (FOH) due to dysregulation of androgen secretion in 1989–1995 …

In fetal females, oogonia proliferate immediately after sex determination. The progress of
mitosis in oogonia proceeds so rapidly that the incompletely divided cytoplasm of the sister …

Objective To study metabolic/inflammatory biomarker risk profiles in women with PCOS and
PCOS offspring. Design Cross-sectional comparison of serum biomarkers. Setting University …

Although only a small number of primordial follicles are known to be selectively activated
during female reproductive cycles, the mechanisms that trigger this recruitment remain …

Well-timed progression of primordial folliculogenesis is essential for mammalian female
fertility. Progesterone (P4) inhibits primordial follicle formation under physiological …

Sustained stimulation of G-protein-coupled receptors (GPCRs) typically causes receptor
desensitisation, which is mediated by phosphorylation, often within the C-terminal tail of the …

Substantive evidence has indicated that the sympathetic innervation contributes to the
regulation and development of ovarian functions. Norepinephrine (NE) is one of the major …

Follicle-stimulating hormone (FSH) and KIT signaling are required for ovarian development.
In this study the interactive effect of FSH and stem cell factor (SCF) on folliculogenesis was …

A large number of oocytes in the perinatal ovary in rodents get lost for unknown reasons.
The granulosa cell–oocyte mutual communication is pivotal for directing formation of the …

Follicle development requires complex and coordinated interactions between both the
oocyte and its associated somatic cells. In ovarian dysfunction, follicle development may be …