Myocardial ischaemia–reperfusion injury and cardioprotection in perspective

G Heusch - Nature Reviews Cardiology, 2020 - nature.com
Despite the increasing use and success of interventional coronary reperfusion strategies,
morbidity and mortality from acute myocardial infarction are still substantial. Myocardial …

Angiogenesis after acute myocardial infarction

X Wu, MR Reboll, M Korf-Klingebiel… - Cardiovascular …, 2021 - academic.oup.com
Acute myocardial infarction (MI) inflicts massive injury to the coronary microcirculation
leading to vascular disintegration and capillary rarefication in the infarct region. Tissue …

The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge

G Heusch, BJ Gersh - European heart journal, 2017 - academic.oup.com
The incidence of ST segment elevation myocardial infarction (STEMI) has decreased over
the last two decades in developed countries, but mortality from STEMI despite widespread …

Coronary microvascular obstruction: the new frontier in cardioprotection

G Heusch - Basic Research in Cardiology, 2019 - Springer
Cardioprotection aims at infarct size reduction and improvement of clinical outcome from
myocardial infarction. The translation of cardioprotection from preclinical and promising …

Cardiovascular remodelling in coronary artery disease and heart failure

G Heusch, P Libby, B Gersh, D Yellon, M Böhm… - The Lancet, 2014 - thelancet.com
Remodelling is a response of the myocardium and vasculature to a range of potentially
noxious haemodynamic, metabolic, and inflammatory stimuli. Remodelling is initially …

Coronary microvascular obstruction in acute myocardial infarction

G Niccoli, G Scalone, A Lerman… - European heart …, 2016 - academic.oup.com
The success of a primary percutaneous intervention (PCI) in the setting of ST elevation
myocardial infarction depends on the functional and structural integrity of coronary …

Coronary microvascular dysfunction: mechanisms and functional assessment

PG Camici, G d'Amati, O Rimoldi - Nature Reviews Cardiology, 2015 - nature.com
Obstructive disease of the epicardial coronary arteries was recognized as the cause of
angina pectoris> 2 centuries ago, and sudden thrombotic occlusion of an epicardial …

The molecular mechanisms of iron metabolism and its role in cardiac dysfunction and cardioprotection

T Ravingerová, L Kindernay, M Barteková… - International journal of …, 2020 - mdpi.com
Iron is an essential mineral participating in different functions of the organism under
physiological conditions. Numerous biological processes, such as oxygen and lipid …

The coronary circulation in acute myocardial ischaemia/reperfusion injury: a target for cardioprotection

DJ Hausenloy, W Chilian, F Crea… - Cardiovascular …, 2019 - academic.oup.com
The coronary circulation is both culprit and victim of acute myocardial infarction. The rupture
of an epicardial atherosclerotic plaque with superimposed thrombosis causes coronary …

Comprehensive prognosis assessment by CMR imaging after ST-segment elevation myocardial infarction

I Eitel, S De Waha, J Wöhrle, G Fuernau, P Lurz… - Journal of the American …, 2014 - jacc.org
Background: Although the prognostic value of findings from cardiac magnetic resonance
(CMR) imaging has been established in single-center center studies in patients with ST …