Halogenated antimicrobial agents to combat drug-resistant pathogens

OS Faleye, BR Boya, JH Lee, I Choi, J Lee… - Pharmacological …, 2024 - Elsevier
Antimicrobial resistance presents us with a potential global crisis as it undermines the
abilities of conventional antibiotics to combat pathogenic microbes. The history of …

Cancer drug-tolerant persister cells: from biological questions to clinical opportunities

M Russo, M Chen, E Mariella, H Peng… - Nature Reviews …, 2024 - nature.com
The emergence of drug resistance is the most substantial challenge to the effectiveness of
anticancer therapies. Orthogonal approaches have revealed that a subset of cells, known as …

Electrochemical determination of levofloxacin using poly (pyrogallol red) modified glassy carbon electrode

ÇC Koçak, B Aslışen, Ş Karabiberoğlu… - …, 2022 - Wiley Online Library
In this paper, an electrochemical sensor for levofloxacin detection was developed by
electrochemical polymerization of pyrogallol red (PGR) on the glassy carbon electrode …

Proton motive force inhibitors are detrimental to methicillin-resistant staphylococcus aureus strains

SG Mohiuddin, S Ghosh, P Kavousi… - Microbiology …, 2022 - Am Soc Microbiol
Methicillin-resistant Staphylococcus aureus (MRSA) strains are tolerant of conventional
antibiotics, making them extremely dangerous. Previous studies have shown the …

(P) ppGpp synthetase Rsh participates in rifampicin tolerance of persister cells in Brucella abortus in vitro

X Liu, P Wang, Y Shi, Y Cui, S Li, GW Dong, J Li… - Microbial …, 2023 - Elsevier
Brucella abortus is facultative intracellular pathogen that causes chronic persistent infections
and results in abortion and infertility in food animals. Recurrent infections can be one of the …

New phenothiazine conjugates as apoptosis inducing agents: Design, synthesis, In-vitro anti-cancer screening and 131I-radiolabeling for in-vivo evaluation

MO Sarhan, H Haffez, NA Elsayed, RS El-Haggar… - Bioorganic …, 2023 - Elsevier
Phenothiazines (PTZs) are a group of compounds characterized by the presence of the 10H-
dibenzo-[b, e]-1, 4-thiazine system. PTZs used in clinics as antipsychotic drugs with other …

Exploring the links between SOS response, mutagenesis, and resistance during the recovery period

S Ghosh, MA Orman - Antimicrobial Agents and Chemotherapy, 2024 - Am Soc Microbiol
Although the mechanistic connections between SOS-induced mutagenesis and antibiotic
resistance are well established, our current understanding of the impact of SOS response …

Proton motive force and antibiotic tolerance in bacteria

Y Wan, J Zheng, EWC Chan, S Chen - Microbial biotechnology, 2024 - Wiley Online Library
Bacterial antibiotic tolerance is a decades‐old phenomenon in which a bacterial sub‐
population, commonly known as persisters, does not respond to antibiotics and remains …

Unraveling Crp/cAMP-mediated metabolic regulation in Escherichia coli persister cells

HG Ngo, SG Mohiuddin, A Ananda, MA Orman - bioRxiv, 2024 - pmc.ncbi.nlm.nih.gov
A substantial gap persists in our comprehension of how bacterial metabolism undergoes
rewiring during the transition to a persistent state. Also, it remains unclear which metabolic …

Unveiling the critical roles of cellular metabolism suppression in antibiotic tolerance

SG Mohiuddin, H Ngo, MA Orman - npj Antimicrobials and Resistance, 2024 - nature.com
Metabolic inhibitors are known to exhibit complex interactions with antibiotics in bacteria,
potentially acting as antagonists by inducing cell dormancy and promoting cell survival …