Autophagy is a conserved intracellular pathway that delivers cytoplasmic contents to
lysosomes for degradation via double-membrane autophagosomes. Autophagy substrates …

Healthy cells use autophagy as a general'housekeeping'mechanism and to survive stress,
including stress induced by nutrient deprivation. Autophagy is initiated at the isolation …

Although the transition metal copper (Cu) is an essential nutrient that is conventionally
viewed as a static cofactor within enzyme active sites, a non-traditional role for Cu as a …

Mammalian cell homeostasis during starvation depends on initiation of autophagy by
endoplasmic reticulum-localized phosphatidylinositol 3-phosphate (PtdIns (3) P) synthesis …

Summary The Keap1-Nrf2 system and autophagy are both involved in the oxidative-stress
response, metabolic pathways, and innate immunity, and dysregulation of these processes …

The ability of cells to respond to changes in nutrient availability is essential for the
maintenance of metabolic homeostasis and viability. One of the key cellular responses to …

It is not clear to what extent starvation-induced autophagy affects the proteome on a global
scale and whether it is selective. In this study, we report based on quantitative proteomics …

Autophagy eliminates dysfunctional mitochondria in an intricate process known as
mitophagy. ULK 1 is critical for the induction of autophagy, but its substrate (s) and …

Mycobacterium tuberculosis, a major global health threat, replicates in macrophages in part
by inhibiting phagosome–lysosome fusion, until interferon-γ (IFNγ) activates the …

Autophagy is a catabolic 'self-eating'pathway that is emerging as a crucial integration point
in cell physiology. With its own set of genes, the autophagy pathway communicates with …